ArticleScientific reports2018
Low-level Gestational Lead Exposure Alters Dendritic Spine Plasticity in the Hippocampus and Reduces Learning and Memory in Rats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 59 citations in OpenAlex.
- Molecular and cellular mechanisms of lead-induced neurotoxicity: comparative insights from rodent and zebrafish models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- R-loop landscapes in the developing human brain are linked to neural differentiation and cell type-specific transcription.Translational psychiatry · 2026Article
- Perinatal exposure to metal mixtures disrupts neuronal function and behavior.Environmental research · 2026Article
- Lipidomic and neurobehavioral alterations from developmental lead exposure in zebrafish.Journal of hazardous materials · 2026Article
- Perinatal Exposure to Metal Mixtures Disrupts Neuronal Function and Behavior.bioRxiv : the preprint server for biology · 2025Article
- Persistent Metabolic Changes Are Induced by 24 h Low-Dose Lead (Pb) Exposure in Zebrafish Embryos.International journal of molecular sciences · 2025Article
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- An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents.Environmental health perspectives · 2024Article
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- Associations of an industry-relevant metal mixture with verbal learning and memory in Italian adolescents: The modifying role of iron status.Environmental research · 2023Article
- Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?International journal of molecular sciences · 2022Article
- Parental Lead Exposure Promotes Neurobehavioral Disorders and Hepatic Dysfunction in Mouse Offspring.Biological trace element research · 2022Article
- A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation.Toxicology reports · 2022Article
- Exposure of metal toxicity in Alzheimer's disease: An extensive review.Frontiers in pharmacology · 2022Review
- Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits.Molecular brain · 2021Article
- Persistent organic pollutants at the synapse: Shared phenotypes and converging mechanisms of developmental neurotoxicity.Developmental neurobiology · 2021Review
- D-serine reduces memory impairment and neuronal damage induced by chronic lead exposure.Neural regeneration research · 2021Article
- DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.Environmental epigenetics · 2021Article
- Maternal Lead Exposure Impairs Offspring Learning and Memory via Decreased GLUT4 Membrane Translocation.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb) is known to impair children's cognitive function. It has been previously shown that developmental Pb exposure alters dendritic spine formation in hippocampal pyramidal neurons. However, the underlying mechanism has not yet been defined. In this study, a low-level gestational Pb exposure (GLE) rat model was employed to investigate the impact of Pb on the spine density of the hippocampal pyramidal neurons and its regulatory mechanism. Pb exposure resulted in impaired performance of the rats in the Morris water maze tasks, and in decreased EPSC amplitudes in hippocampal CA3-CA1 regions. With a 3D reconstruction by the Imaris software, the results from Golgi staining showed that the spine density in the CA1 region was reduced in the Pb-exposed rats in a dose-dependent manner. Decreased spine density was also observed in cultured hippocampal neurons following the Pb treatment. Furthermore, the expression level of NLGN1, a postsynaptic protein that mediates synaptogenesis, was significantly decreased following the Pb exposure both in vivo and in vitro. Up-regulation of NLGN1 in cultured primary neurons partially attenuated the impact of Pb on the spine density. Taken together, our resultssuggest that Pb exposure alters spine plasticity in the developing hippocampus by down-regulating NLGN1 protein levels.
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