ArticleScientific reports2018
Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Design and development of a high-throughput multipattern aerosol deposition device for respiratory toxicity and health-risk assessment (MARTHA).Journal of aerosol science · 2026Article
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Article
- Cellular responses of lung cells cultured at an Air-liquid Interface are influenced by spatial nanoparticle deposition patterns in anAerosol science and technology : the journal of the American Association for Aerosol Research · 2025Article
- Changes in lung mechanics and ventilation-perfusion match: comparison of pulmonary air- and thromboembolism in rats.BMC pulmonary medicine · 2024Article
- Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence.Annals of biomedical engineering · 2023Article
- Chemical and Cellular Formation of Reactive Oxygen Species from Secondary Organic Aerosols in Epithelial Lining Fluid.Research report (Health Effects Institute) · 2023Article
- Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells inJournal of aerosol medicine and pulmonary drug delivery · 2023Article
- Imaging drug delivery to the lungs: Methods and applications in oncology.Advanced drug delivery reviews · 2023Review
- Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes.Environmental science & technology · 2022Article
- Article
- The physics of respiratory particle generation, fate in the air, and inhalation.Nature reviews. Physics · 2022Review
- Simple low dose radiography allows precise lung volume assessment in mice.Scientific reports · 2021Article
- Methods for dynamic synchrotron X-ray respiratory imaging in live animals.Journal of synchrotron radiation · 2020Article
- Full-field spectroscopic measurement of the X-ray beam from a multilayer monochromator using a hyperspectral X-ray camera.Journal of synchrotron radiation · 2020Article
- X-ray-Based 3D Virtual Histology-Adding the Next Dimension to Histological Analysis.Molecular imaging and biology · 2018Review
- Gas Partial Pressure in Cultured Cells: Patho-Physiological Importance and Methodological Approaches.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the determinants of inhaled aerosol particle distribution and targeting in the lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial. No single imaging modality allows the acquisition of all such data together. Here we assessed the feasibility of dual-energy synchrotron radiation imaging to this end in anesthetized rabbits; both in normal lung (n = 6) and following methacholine (MCH)-induced bronchoconstriction (n = 6), a model of asthma. We used K-edge subtraction CT (KES) imaging to quantitatively map the regional deposition of iodine-containing aerosol particles. Morphological and regional ventilation images were obtained, followed by quantitative regional iodine deposition maps, after 5 and 10 minutes of aerosol administration. Iodine deposition was markedly inhomogeneous both in normal lung and after induced bronchoconstrition. Deposition was significantly reduced in the MCH group at both time points, with a strong dependency on inspiratory flow in both conditions (R
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