Evidence map›Paper›PMID 29476080›Full record

ArticleScientific reports2018

Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression.

Shiferaw Jenberie, Hanna L Thim, J Oriol Sunyer, Karsten Skjødt, Ingvill Jensen, Jorunn B Jørgensen

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Plasmid-DNA EncodedPharmaceutics · 2026
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  14. Profiling the Atlantic Salmon IgMFrontiers in immunology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Shiferaw JenberieNorwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
Hanna L ThimNorwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
J Oriol SunyerDepartment of Pathology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
Karsten SkjødtDepartment of Immunology and Microbiology, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark.
Ingvill JensenNorwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
Jorunn B JørgensenNorwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. jorunn.jorgensen@uit.no.
UiT The Arctic University of Norway · NOUniversity of Pennsylvania · USUniversity of Southern Denmark · DK

Funding

Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune ResponsesR01GM085207 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNYER, J. ORIOL · 2010 to 2022
$3.8M
NIGMS NIH HHS R01 GM085207
6 · The paper itself

Abstract

While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM

Indexed as

AnimalsB-LymphocytesCell LineageCpG IslandsGene Expression RegulationImmunoglobulin MInterferon-alphaSalmo salarToll-Like ReceptorsImmunoglobulin MInterferon-alphasecretory IgMToll-Like Receptors

Identifiers

PMID29476080
PMCPMC5824956
OpenAlexW2791878314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.