Evidence map›Paper›PMID 29476045›Full record

ReviewAging2018

Heart rate variability as predictive factor for sudden cardiac death.

Francesco Sessa, Valenzano Anna, Giovanni Messina, Giuseppe Cibelli, Vincenzo Monda, Gabriella Marsala, Maria Ruberto, Antonio Biondi, Orazio Cascio, Giuseppe Bertozzi and 5 more

Open access · greenAbstract readReview
In one paragraph

Review in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 4 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 4 syntheses or guidelines pooled it, 304 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.Heart views : the official journal of the Gulf Heart Association · 2026
    Review

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Francesco Sessa *University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Valenzano Anna *University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Giovanni MessinaUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Giuseppe CibelliUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Vincenzo MondaUniversità degli Studi di Napoli Federico II, Department of Experimental Medicine, Naples, Italy.
Gabriella MarsalaStruttura Complessa di Farmacia, Azienda Ospedaliero-Universitaria, Foggia, Italy.
Maria RubertoCRD Center, Santa Maria del Pozzo, Somma Vesuviana (NA), Italy.
Antonio BiondiUniversity of Catania, Department of Surgery, Catania, Italy.
Orazio CascioUniversity of Catania, Department of Anatomy, Catania, Italy.
Giuseppe BertozziUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Daniela PisanelliUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Francesca MagliettaUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
Antonietta MessinaUniversità degli Studi di Napoli Federico II, Department of Experimental Medicine, Naples, Italy.
Maria P MollicaUniversità degli Studi di Napoli Federico II, Department of Experimental Medicine, Naples, Italy.
Monica SalernoUniversity of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
University of Foggia · ITUniversity of Naples Federico II · ITUniversity of Catania · ITOspedali Riuniti di Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sudden cardiac death (SCD) represents about 25% of deaths in clinical cardiology. The identification of risk factors for SCD is the philosopher's stone of cardiology and the identification of non-invasive markers of risk of SCD remains one of the most important goals for the scientific community.The aim of this review is to analyze the state of the art around the heart rate variability (HRV) as a predictor factor for SCD.HRV is probably the most analyzed index in cardiovascular risk stratification technical literature, therefore an important number of models and methods have been developed.Nowadays, low HRV has been shown to be independently predictive of increased mortality in post- myocardial infarction patients, heart failure patients, in contrast with the data of the general population.Contrariwise, the relationship between HRV and SCD has received scarce attention in low-risk cohorts. Furthermore, in general population the attributable risk is modest and the cost/benefit ratio is not always convenient.The HRV evaluation could become an important tool for health status in risks population, even though the use of HRV alone for risk stratification of SCD is limited and further studies are needed.

Indexed as

Heart RateAsymptomatic DiseasesDeath, Sudden, CardiacElectrocardiographyFemaleHumansMaleMass ScreeningRisk Factorscardiovascular diseasesheartheart rateheart rate variabilitysudden cardiac death

Identifiers

PMID29476045
PMCPMC5842851
OpenAlexW2790041106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.