Evidence map›Paper›PMID 29476043›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

Targeting Epigenetics to Prevent Obesity Promoted Cancers.

Nathan A Berger, Peter C Scacheri

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Epigenetic effects of high-fat diet on intestinal tumorigenesis in C57BL/6J-Journal of translational genetics and genomics · 2023
    Article
  2. Article
  3. Article
  4. Ketotherapy as an epigenetic modifier in cancer.Reviews in endocrine & metabolic disorders · 2020
    Review
  5. Impact of bariatric surgery on cancer risk reduction.Annals of translational medicine · 2020
    Review
  6. Review
  7. NovelJournal of clinical medicine · 2019
    Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nathan A BergerDepartment of Medicine, Center for Science, Health & Society, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. nab@case.edu.
Peter C ScacheriDepartment of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Funding

Targeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6M
Whole Exome Approaches for Esophageal Adenocarcinoma Susceptibility GenesU54CA163060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAK, AMITABH, GUDA, KISHORE · 2011 to 2022
$14.0M
Inherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4M
The role of gene enhancer elements in colon cancerR01CA160356 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TESAR, PAUL JOSEPH · 2012 to 2023
$3.6M
Biology of Colorectal Cancer Risk EnhancersR01CA204279 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM, SCACHERI, PETER CHRISTOPHER · 2016 to 2020
$3.0M
Role of enhancer elements in regulating prometastatic transcriptional programs in osteosarcomaR01CA193677 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI SCACHERI, PETER CHRISTOPHER · 2016 to 2020
$1.8M
NCI NIH HHS P50 CA150964NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA160356NCI NIH HHS R01 CA193677NCI NIH HHS R01 CA204279NCI NIH HHS U54 CA163060
6 · The paper itself

Abstract

Epigenetic changes in DNA and associated chromatin proteins are increasingly being considered as important mediators of the linkage between obesity and cancer. Although multiple agents, targeted at epigenetic changes, are being tested for therapy of established cancers, this issue of

Indexed as

AdiposityEpigenesis, GeneticCell Transformation, NeoplasticHumansNeoplasmsObesity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.