ArticleMolecular pharmacology2018
Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin.
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Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Heme-NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties.International journal of molecular sciences · 2023Article
- Artifacts Introduced by Sample Handling in Chemiluminescence Assays of Nitric Oxide Metabolites.Antioxidants (Basel, Switzerland) · 2023Article
- Chronic High-Altitude Hypoxia Alters Iron and Nitric Oxide Homeostasis in Fetal and Maternal Sheep Blood and Aorta.Antioxidants (Basel, Switzerland) · 2022Article
- A physiologically relevant role for NO stored in vascular smooth muscle cells: A novel theory of vascular NO signaling.Redox biology · 2022Review
- Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury.PloS one · 2022Article
- Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?Drug design, development and therapy · 2022Article
- Kinetics of Azanone (HNO) Reactions with Thiols: Effect of pH.Cell biochemistry and biophysics · 2021Article
- Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity.International journal of molecular sciences · 2021Review
- Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19.Biophysics · 2021Article
- Deferoxamine produces nitric oxide under ferricyanide oxidation, blood incubation, and UV-irradiation.Free radical biology & medicine · 2020Article
- Evidence for placental-derived iron-nitrosyls in the circulation of the fetal lamb and against a role for nitrite in mediating the cardiovascular transition at birth.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism-Review.Molecules (Basel, Switzerland) · 2020Review
- The role of gasotransmitters in neonatal physiology.Nitric oxide : biology and chemistry · 2020Review
- L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation.Redox biology · 2019Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Taiming LiuDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Meijuan ZhangDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Michael H TerryDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Hobe SchroederDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Sean M WilsonDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Gordon G PowerDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Qian LiDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Trent E TippleDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Dan BorchardtDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.).
Arlin B BloodDivision of Neonatology, Department of Pediatrics (T.L., M.Z., A.B.B.), Department of Respiratory Care (M.H.T.), and Center for Perinatal Biology (H.S., S.M.W., G.G.P., A.B.B.), Loma Linda University School of Medicine, Loma Linda, California; Neonatal Redox Biology Laboratory, Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama (Q.L., T.E.T.); and Department of Chemistry, University of California, Riverside, California (D.B.) ablood@llu.edu.
University of California, Riverside · USLoma Linda University · USUniversity of Alabama at Birmingham · US
Funding
Uterine vascular responses to pregnancy and long term hypoxemiaP01HD031226 · NICHD · LOMA LINDA UNIVERSITY · PI LONGO, LAWRENCE D · 1995 to 2014
$21.4MUterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3MTargeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary DysplasiaR01HL119280 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIPPLE, TRENT · 2014 to 2018
$2.0MRole of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adultR01HL095973 · NHLBI · LOMA LINDA UNIVERSITY · PI BLOOD, ARLIN B · 2009 to 2013
$1.9MIntrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteriesR03HD069746 · NICHD · LOMA LINDA UNIVERSITY · PI WILSON, SEAN M · 2012 to 2013
$145kNHLBI NIH HHS R01 HL095973NHLBI NIH HHS R01 HL119280NICHD NIH HHS P01 HD031226NICHD NIH HHS P01 HD083132NICHD NIH HHS R03 HD069746
Abstract
Glutathione-liganded binuclear dinitrosyl iron complex (glut-BDNIC) has been proposed to be a donor of nitric oxide (NO). This study was undertaken to investigate the mechanisms of vasoactivity, systemic hemodynamic effects, and pharmacokinetics of glut-BDNIC. To test the hypothesis that glut-BDNICs vasodilate by releasing NO in its reduced [nitroxyl (HNO)] state, a bioassay method of isolated, preconstricted ovine mesenteric arterial rings was used in the presence of selective scavengers of HNO or NO free radical (NO
Indexed as
AnimalsAntihypertensive AgentsElectron Spin Resonance SpectroscopyFemaleGlutathioneHemodynamicsIronLigandsMaleMesenteric ArteriesMyographyNitric Oxide DonorsNitrogen OxidesRatsSerum AlbuminSheepAntihypertensive Agentsdinitrosyl iron complexGlutathioneIronLigandsNitric Oxide DonorsNitrogen OxidesnitroxylSerum AlbuminVasodilator Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.