ArticleNeurology2018
Attention-deficit/hyperactivity disorder medication and seizures.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epilepsy and attention-deficit/hyperactivity disorder in children and adolescents: An overview of etiology, prevalence, and treatment.Frontiers in human neuroscience · 2023Pooled it
- Psychiatric Comorbidities in Pediatric Epilepsy.Current psychiatry reports · 2020Pooled it
- Risks and Benefits of Attention-Deficit/Hyperactivity Disorder Medication on Behavioral and Neuropsychiatric Outcomes: A Qualitative Review of Pharmacoepidemiology Studies Using Linked Prescription Databases.Biological psychiatry · 2019Pooled it
- Long term safety of ADHD medication in patients with schizophrenia spectrum disorders.Molecular psychiatry · 2025Article
- ADHD in Adults with Epilepsy: A Guide for Neurologists.Epilepsy & behavior reports · 2025Article
- A Narrative Review of Outcomes, Comorbidities, and Alternative Behavioral Interventions in Adolescent and Adult Women with ADHD.International journal of women's health · 2025Review
- Children with ADHD and EEG abnormalities at baseline assessment, risk of epileptic seizures and maintenance on methylphenidate three years later.Annals of general psychiatry · 2024Article
- Do psychotropic drugs cause seizures?Epilepsy & behavior reports · 2024Article
- Should neurologists treat common psychiatric comorbidities in patients with epilepsy?Epilepsy & behavior reports · 2024Article
- Comorbidity of attention deficit hyperactivity disorder in a patient with epilepsy: Staring down the challenge of inattention versus nonconvulsive seizures.Epilepsy & behavior reports · 2024Review
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- The association between early childhood onset epilepsy and attention-deficit hyperactivity disorder (ADHD) in 3237 children and adolescents with Autism Spectrum Disorder (ASD): a historical longitudinal cohort data linkage study.European child & adolescent psychiatry · 2023Article
- Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges.International journal of molecular sciences · 2023Review
- Mainstreaming adult ADHD into primary care in the UK: guidance, practice, and best practice recommendations.BMC psychiatry · 2022Article
- Protective Effect of Escitalopram on Hepatocellular Carcinoma by Inducing Autophagy.International journal of molecular sciences · 2022Article
- Do Psychotropic Drugs Cause Epileptic Seizures? A Review of the Available Evidence.Current topics in behavioral neurosciences · 2022Review
- Methylphenidate for attention problems in epilepsy patients: Safety and efficacy.Epilepsy & behavior : E&B · 2021Review
- Drug Treatment of Epilepsy Neuropsychiatric Comorbidities in Children.Paediatric drugs · 2021Review
- Depression and Suicidal Behavior in Young Adult Men and Women With ADHD: Evidence From Claims Data.The Journal of clinical psychiatry · 2020Article
- Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy.Epilepsia · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveIndividuals with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of seizures, but there is uncertainty about whether ADHD medication treatment increases risk among patients with and without preexisting seizures.
methodsWe followed a sample of 801,838 patients with ADHD who had prescribed drug claims from the Truven Health MarketScan Commercial Claims and Encounters databases to examine whether ADHD medication increases the likelihood of seizures among ADHD patients with and without a history of seizures. First, we assessed overall risk of seizures among patients with ADHD. Second, within-individual concurrent analyses assessed odds of seizure events during months when a patient with ADHD received ADHD medication compared with when the same individual did not, while adjusting for antiepileptic medications. Third, within-individual long-term analyses examined odds of seizure events in relation to the duration of months over the previous 2 years patients received medication.
resultsPatients with ADHD were at higher odds for any seizure compared with non-ADHD controls (odds ratio [OR] = 2.33, 95% confidence interval [CI] = 2.24-2.42 males; OR = 2.31, 95% CI = 2.22-2.42 females). In adjusted within-individual comparisons, ADHD medication was associated with lower odds of seizures among patients with (OR = 0.71, 95% CI = 0.60-0.85) and without (OR = 0.71, 95% CI = 0.62-0.82) prior seizures. Long-term within-individual comparisons suggested no evidence of an association between medication use and seizures among individuals with (OR = 0.87, 95% CI = 0.59-1.30) and without (OR = 1.01, 95% CI = 0.80-1.28) a seizure history.
conclusionsResults reaffirm that patients with ADHD are at higher risk of seizures. However, ADHD medication was associated with lower risk of seizures within individuals while they were dispensed medication, which is not consistent with the hypothesis that ADHD medication increases risk of seizures.
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Registered trials
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