Evidence map›Paper›PMID 29476019›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2018

Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer.

Silvia C Formenti, Percy Lee, Sylvia Adams, Judith D Goldberg, Xiaochun Li, Mike W Xie, Josephine A Ratikan, Carol Felix, Lin Hwang, Kym F Faull and 7 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 2 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 2 syntheses or guidelines pooled it, 241 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. The immunology of human breast cancer.Nature reviews. Immunology · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  10. Review
  11. Cytokines and cancer-associated fibroblasts.Journal of hematology & oncology · 2026
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Silvia C FormentiDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY. wmcbride@mednet.ucla.edu formenti@med.cornell.edu.
Percy LeeDepartment of Radiation Oncology, University of California, Los Angeles, California.
Sylvia AdamsDepartment of Medicine, New York University School of Medicine, New York, NY.
Judith D GoldbergDepartment of Population Health, New York University School of Medicine, New York, NY.ORCID 0000-0003-3758-6976
Xiaochun LiDepartment of Population Health, New York University School of Medicine, New York, NY.
Mike W XieDepartment of Radiation Oncology, University of California, Los Angeles, California.
Josephine A RatikanDepartment of Radiation Oncology, University of California, Los Angeles, California.
Carol FelixDepartment of Radiation Oncology, University of California, Los Angeles, California.
Lin HwangJonsson Compressive Cancer Center, University of California, Los Angeles, California.
Kym F FaullPasarow Mass Spectrometry Laboratory at University of California, Los Angeles, California.
James W SayrePublic Health Biostatistics at University of California, Los Angeles, California.
Sara HurvitzJonsson Compressive Cancer Center, University of California, Los Angeles, California.
John A GlaspyJonsson Compressive Cancer Center, University of California, Los Angeles, California.
Begoña Comin-AnduixJonsson Compressive Cancer Center, University of California, Los Angeles, California.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY.
Dörthe Schaue *Department of Radiation Oncology, University of California, Los Angeles, California.
William H McBride *Department of Radiation Oncology, University of California, Los Angeles, California. wmcbride@mednet.ucla.edu formenti@med.cornell.edu.
University of California, Los Angeles · USNew York University · USCornell University · USProtéomique, Réponse Inflammatoire et Spectrométrie de Masse · FRUniversity of Baltimore · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Institutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL, HOCHMAN, JUDITH S · 2012 to 2014
$16.8M
Radiotherapy-induced tumor immunityR01CA191234 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHAUE, DORTHE · 2015 to 2019
$1.8M
NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA191234
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RadiotherapyAdultAgedAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBiomarkersBreast NeoplasmsCombined Modality TherapyDrug MonitoringFemaleHumansMiddle AgedMolecular Targeted TherapyNeoplasm MetastasisNeoplasm StagingPositron Emission Tomography Computed TomographyAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBiomarkersfresolimumabTransforming Growth Factor beta

Identifiers

PMID29476019
PMCPMC5999326
OpenAlexW2789720205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.