ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Systemic corticosterone enhances fear memory extinction in rats: Involvement of the infralimbic medial prefrontal cortex GABABrain and behavior · 2024Article
- Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.International journal of molecular sciences · 2024Article
- Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats.Molecular neurobiology · 2022Article
- Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.Biological psychiatry · 2022Article
- Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace.Frontiers in molecular neuroscience · 2022Review
- Genistein enhances expression of extracellular regulated kinases (ERK) 1/2, and learning and memory of mouse.IBRO neuroscience reports · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Active Transition of Fear Memory Phase from Reconsolidation to Extinction through ERK-Mediated Prevention of Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between.Frontiers in behavioral neuroscience · 2020Review
- Retrieval-Extinction and Relapse Prevention: Rewriting Maladaptive Drug Memories?Frontiers in behavioral neuroscience · 2020Review
- Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats.Neurobiology of learning and memory · 2019Article
- Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats.Behavioural brain research · 2019Article
- Fear not: recent advances in understanding the neural basis of fear memories and implications for treatment development.F1000Research · 2019Review
- Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories.Frontiers in molecular neuroscience · 2019Review
- Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction.Frontiers in molecular neuroscience · 2019Article
- Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.Psychopharmacology · 2019Review
- Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory.Frontiers in molecular neuroscience · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Fully consolidated fear memories can be maintained or inhibited by retrieval-dependent mechanisms depending on the degree of re-exposure to fear cues. Short exposures promote memory maintenance through reconsolidation, and long exposures promote inhibition through extinction. Little is known about the neural mechanisms by which increasing cue exposure overrides reconsolidation and instead triggers extinction. Using auditory fear conditioning in male rats, we analyzed the role of a molecular mechanism common to reconsolidation and extinction of fear, ERK1/2 activation within the basolateral amygdala (BLA), after intermediate conditioned stimulus (CS) exposure events. We show that an intermediate re-exposure (four CS presentations) failed to activate ERK1/2 in the BLA, suggesting the absence of reconsolidation or extinction mechanisms. Supporting this hypothesis, pharmacologically inhibiting the BLA ERK1/2-dependent signaling pathway in conjunction with four CS presentations had no effect on fear expression, and the NMDA receptor partial agonist d-cycloserine, which enhanced extinction and ERK1/2 activation in partial extinction protocols (seven CSs), had no behavioral or molecular effect when given in association with four CS presentations. These molecular and behavioral data reveal a novel retrieval-dependent memory phase occurring along the transition between conditioned fear maintenance and inhibition. CS-dependent molecular events in the BLA may arrest reconsolidation intracellular signaling mechanism in an extinction-independent manner. These findings are critical for understanding the molecular underpinnings of fear memory persistence after retrieval both in health and disease.
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