Evidence map›Paper›PMID 29476014›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis.

Natasha Warikoo, Samuel J Brunwasser, Ann Benz, Hong-Jin Shu, Steven M Paul, Michael Lewis, James Doherty, Michael Quirk, Laura Piccio, Charles F Zorumski and 2 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04372615 (A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-Nmda Receptor Encephalitis and Assess Markers of Disease), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04372615 phase2recruitingnot on this mapstarted 2022, after this paper: background citation

A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-Nmda Receptor Encephalitis and Assess Markers of Disease

TypeinterventionalSponsorUniversity of UtahRan2022 to 2028Enrolled116ConditionsAutoimmune Encephalitis, EncephalitisArmsInebilizumab, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Oxysterols in Central and Peripheral Synaptic Communication.Advances in experimental medicine and biology · 2024
    Article
  9. Article
  10. Review
  11. Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice.Neurology(R) neuroimmunology & neuroinflammation · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. TwoeLife · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Natasha WarikooDepartments of Psychiatry.ORCID 0000-0002-8329-7801
Samuel J BrunwasserDepartments of Psychiatry.
Ann BenzDepartments of Psychiatry.
Hong-Jin ShuDepartments of Psychiatry.
Steven M PaulDepartments of Psychiatry.ORCID 0000-0002-8388-2023
Michael LewisSage Therapeutics, Cambridge, Massachusetts 02142.ORCID 0000-0002-4958-6634
James DohertySage Therapeutics, Cambridge, Massachusetts 02142.
Michael QuirkSage Therapeutics, Cambridge, Massachusetts 02142.
Laura PiccioNeurology.
Charles F ZorumskiDepartments of Psychiatry.ORCID 0000-0002-9704-5154
Gregory S DayNeurology.ORCID 0000-0001-5133-5538
Steven MennerickDepartments of Psychiatry, menneris@wustl.edu.ORCID 0000-0003-0868-0664
Sage Therapeutics (United States) · USWashington University in St. Louis · USGaertner (United States) · USNeurology, Inc · USTaylor Family Institute for Innovative Psychiatric ResearchVoyager Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAllosteric RegulationAnimalsCell LineCells, CulturedEncephalitisFemaleHashimoto DiseaseHumansMaleMiceNeurotransmitter AgentsProtein TransportRatsReceptors, N-Methyl-D-AspartateSynaptic PotentialsNeurotransmitter AgentsReceptors, N-Methyl-D-AspartateautoimmuneglutamateNMDA receptorschizophrenia

Identifiers

PMID29476014
PMCPMC6596063
OpenAlexW2788519775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.