ArticleJournal of the American Society of Nephrology : JASN2018
Characterization of Coding/Noncoding Variants for
Open access · bronzeAbstract read
In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Genome-wide association study of hospitalized patients and acute kidney injury.Kidney international · 2024Pooled it
- The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.BMC medical genomics · 2022Pooled it
- Gene modification: Exploring the potential in treating kidney diseases.Pharmacological research · 2026Review
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction.Nature communications · 2025Article
- Mapping Shroom3 expression across the adult mouse.Gene expression patterns : GEP · 2025Article
- Article
- Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension.Journal of the American Society of Nephrology : JASN · 2025Article
- CommonGenome research · 2025Article
- Clinical and Metabolic Signatures ofKidney international reports · 2025Article
- Focus on a CKD-Associated Locus:Kidney international reports · 2025Article
- Pathogenic variants in SHROOM3 associated with hemifacial microsomia.Journal of human genetics · 2025Article
- Personalized Nutrition in Chronic Kidney Disease.Biomedicines · 2025Review
- Article
- Systematic mediation and interaction analyses of kidney function genetic loci in a general population study.PloS one · 2025Article
- Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele.bioRxiv : the preprint server for biology · 2024Article
- The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease.Phenomics (Cham, Switzerland) · 2024Review
- Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care.Biotech (Basel (Switzerland)) · 2024Review
- Population-based discovery and Mendelian randomization analysis identify telmisartan as a candidate medicine for Alzheimer's disease in African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.Nature communications · 2023Article
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 4 countries.
Jeremy W ProkopHudsonAlpha Institute for Biotechnology, Huntsville, Alabama; jprokop54@gmail.com jlazar@hudsonalpha.org.
Nan Cher YeoDepartment of Genetics, Harvard Medical School, Boston, Massachusetts.
Christian OttmannDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Surya B ChhetriHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Kacie L FlorusHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Emily J RossHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Nadiya SosonkinaHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Brian A LinkDepartment of Cell Biology, Neurobiology and Anatomy and.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Candice J CoppolaDepartment of Biological Sciences, The University of Alabama in Huntsville, Huntsville, Alabama.
Chris McDermott-RoeDepartment of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Seppe LeysenDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Lech-Gustav MilroyDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Femke A MeijerDepartment of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Aron M GeurtsDepartment of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Frank J RauscherGene Expression & Regulation Program, Wistar Institute, Philadelphia, Pennsylvania.
Ryne RamakerHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Michael J FlisterDepartment of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Howard J JacobHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Eric M MendenhallHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Jozef LazarHudsonAlpha Institute for Biotechnology, Huntsville, Alabama; jprokop54@gmail.com jlazar@hudsonalpha.org.
HudsonAlpha Institute for Biotechnology · USEindhoven University of Technology · NLMedical College of Wisconsin · USUniversity of Alabama in Huntsville · USHarvard University · USInstitute of Cell Biology and Neurobiology · ITMichigan State University · USThe Wistar Institute · USVanderbilt University · USWake Forest University · US
Funding
Physiological Genomics of Hypertensive Renal DiseaseR01HL069321 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI LAZAR, JOZEF · 2001 to 2017
$5.6MIntegrative Analysis of Vertebrate Retinal LaminationR01EY014167 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 2003 to 2017
$4.6MUsing a Sequence-to-Structure-to-Function Approach to Functionally Characterize Protein Coding Missense Mutations in the Human and Rat GenomesK01ES025435 · NIEHS · MICHIGAN STATE UNIVERSITY · PI PROKOP, JEREMY WILLIAM · 2014 to 2018
$489kNEI NIH HHS R01 EY014167NHLBI NIH HHS R01 HL069321NIEHS NIH HHS K01 ES025435
Abstract
PubMed holds no abstract for this paper.
Indexed as
AllelesAnimalsCell NucleusGene FrequencyGenetic LociHEK293 CellsHumansMiceMicrofilament ProteinsMutation, MissensePodocytesProtein IsoformsRenal Insufficiency, ChronicTranscription Factor 7-Like 2 ProteinTranscription, GeneticZebrafishMicrofilament ProteinsProtein IsoformsShrm protein, mouseSHROOM3 protein, humanTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinCRISPR/Cas9Genomic VariantsGWASRare VariantsSHROOM3TCF7L2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.