Evidence map›Paper›PMID 29475948›Full record

ArticleThe Journal of biological chemistry2018

Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis.

Mohammed A Amin, Richard J McKenney, Dileep Varma

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Measuring and modeling the dynamics of mitotic error correction.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. RZZ-SPINDLY-DYNEIN: you got to keep 'em separated.Cell cycle (Georgetown, Tex.) · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mohammed A AminFrom the Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 and.
Richard J McKenneyDepartment of Molecular and Cellular Biology, University of California, Davis, California 95616.
Dileep VarmaFrom the Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 and dileep.varma@northwestern.edu.
Northwestern University · USUniversity of California, Davis · US

Funding

Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.R35GM124889 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Richard James McKenney · 2017 to 2026
$4.3M
Regulation of Cytoplasmic Dynein Motility in Neuronal TransportR00NS089428 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCKENNEY, RICHARD JAMES · 2016 to 2018
$736k
Role of the Ndc80 Loop Domain and Cdt1 in Kinetochore Microtubule AttachmentsR00CA178188 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VARMA, DILEEP · 2015 to 2017
$660k
NCI NIH HHS R00 CA178188NIGMS NIH HHS R35 GM124889NINDS NIH HHS R00 NS089428
6 · The paper itself

Abstract

Chromosome alignment and segregation during mitosis require kinetochore-microtubule (kMT) attachments that are mediated by the molecular motor dynein and the kMT-binding complex Ndc80. The Rod-ZW10-Zwilch (RZZ) complex is central to this coordination as it has an important role in dynein recruitment and has recently been reported to have a key function in the regulation of stable kMT attachments in

Indexed as

MitosisCytoskeletal ProteinsDyneinsHeLa CellsHumansKinetochoresMicrotubulesNuclear ProteinsProtein BindingCytoskeletal ProteinsDyneinsNDC80 protein, humanNuclear Proteinsalignmentcheckpoint controlchromosomesdyneinHec1kinetochoremicrotubulemitosismitotic spindleNdc80Rodsegregation

Identifiers

PMID29475948
PMCPMC5912454
OpenAlexW2792377418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.