Evidence map›Paper›PMID 29475922›Full record

ArticleIn vivo (Athens, Greece)

DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.

Aki Takiyama, Toshiaki Tanaka, Shinsuke Kazama, Hiroshi Nagata, Kazushige Kawai, Keisuke Hata, Kensuke Otani, Takeshi Nishikawa, Kazuhito Sasaki, Manabu Kaneko and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Intestinal stem cell niche: An upcoming area of immense importance in gastrointestinal disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Aki TakiyamaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan takiyamaa-sur@h.u-tokyo.ac.jp.
Toshiaki TanakaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Shinsuke KazamaDivision of Gastroenterological Surgery, Saitama Cancer Center, Saitama, Japan.
Hiroshi NagataDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Kazushige KawaiDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Keisuke HataDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Kensuke OtaniDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Takeshi NishikawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Kazuhito SasakiDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Manabu KanekoDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Shigenobu EmotoDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Koji MuronoDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Hirotoshi TakiyamaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPSaitama Cancer Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe expression of doublecortin-like kinase 1 (DCLK1) has been investigated in cancer; however not in precancerous adenomatous polyps. MATERIALS AND

methodsImmunohistological expression of DCLK1 was evaluated in various grades of adenomas, cancerous polyps, and hyperplastic polyps in resected human tissue specimens.

resultsNinety-two specimens were positive for DCLK1 and 134 were negative. Cancerous polyps showed a high DCLK1 positivity rate compared to adenomas (68.4% vs. 36.8%; p<0.01). The rate of DCLK1 positivity was not significantly different among the three grades of adenomas (mild, moderate, and severe). DCLK1 was highly positive in advanced adenomas than low risk adenomas (49.6% vs. 29.3%; p<0.01).

conclusionThe expression of DCLK1 was found in low-grade adenomas and increased with worsening severity of dysplasia. DCLK1 expression was highly observed in advanced adenomas, which had a clinically higher malignant potential.

Indexed as

Gene ExpressionAdultAgedAged, 80 and overBiomarkersBiopsyColonic PolypsColorectal NeoplasmsDoublecortin-Like KinasesFemaleHumansHyperplasiaImmunohistochemistryIntracellular Signaling Peptides and ProteinsMaleMiddle AgedBiomarkersDCLK1 protein, humanDoublecortin-Like KinasesIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesCancer stem cellcolorectal adenomacolorectal cancercolorectal polypdoublecortin-like kinase 1

Identifiers

PMID29475922
PMCPMC5905207
OpenAlexW2788418896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.