Evidence map›Paper›PMID 29475911›Full record

ArticleIn vivo (Athens, Greece)

Tumor Necrosis Factor-Alpha (

Selçuk Ozdogan, Cumhur Kaan Yaltirik, Seda Gulec Yilmaz, Mustafa Kaya, Ali Haluk Duzkalir, Nail Demirel, Ali Kafadar, Turgay Isbir

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Selçuk OzdoganDepartment of Neurosurgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
Cumhur Kaan YaltirikDepartment of Neurosurgery, Yeditepe University Faculty of Medicine, Istanbul, Turkey.
Seda Gulec YilmazDepartment of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
Mustafa KayaDepartment of Neurosurgery, Ereğli State Hospital, Zonguldak, Turkey.
Ali Haluk DuzkalirDepartment of Neurosurgery, Dr.Lütfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey.
Nail DemirelDepartment of Neurosurgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
Ali KafadarDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
Turgay IsbirDepartment of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey tur-gay.isbir@yeditepe.edu.tr tisbir@superonline.com.
Yeditepe University · TRBülent Ecevit University · TRDr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · TRIstanbul University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHigh-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligodendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-α -308 G>A polymorphism in a Turkish population. PATIENTS AND

methodsThis was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors.

resultsNo significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598).

conclusionTNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.

Indexed as

AllelesPolymorphism, Single NucleotideAdultCase-Control StudiesFemaleGene FrequencyGenotypeGliomaHumansMaleMiddle AgedNeoplasm GradingTumor Necrosis Factor-alphaYoung AdultTumor Necrosis Factor-alphahigh-grade gliomaspolymorphismTumor necrosis factor

Identifiers

PMID29475911
PMCPMC5905196
OpenAlexW2787894474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.