ArticleIn vivo (Athens, Greece)
Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Anti-Bacterial, Anti-Viral, and Anti-Inflammatory Properties of Kumazasa Extract: A Potential Strategy to Regulate Smoldering and Inflammation.Medicina (Kaunas, Lithuania) · 2025Article
- Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue.Medicines (Basel, Switzerland) · 2021Article
- Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta-Induced Toxicity.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Curcumin, Hormesis and the Nervous System.Nutrients · 2019Review
- Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method.Molecules (Basel, Switzerland) · 2018Article
- Dental Application of Natural Products.Medicines (Basel, Switzerland) · 2018Review
- Does Green Tea Induce Hormesis?Dose-response : a publication of International Hormesis SocietyArticle
- Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.In vivo (Athens, Greece)Article
- Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells.In vivo (Athens, Greece)Article
- Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.In vivo (Athens, Greece)Article
- Prominent Anti-UVC Activity of Lignin Degradation Products.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimWe have previously reported the protection of doxorubicin-induced keratinocyte toxicity by alkaline extract of the leaves of Sasa senanensis Rehder (SE). In order to extend the generality of the cell protective effect of SE, we investigated whether it also protects rat PC12 and human SH-SY5Y neuron model cells from amyloid β-peptide (Aβ)-induced injury. MATERIALS AND
methodsViability of cells was determined by the MTT method. Cytotoxicity was evaluated by the concentration that reduces the cell viability by 50% (CC
resultsSE showed hormetic growth stimulation at lower concentrations in both neuron precursors and differentiated cells. SE reproducibly inhibited Aβ-induced cytotoxicity against both undifferentiated and differentiated neuron cells. Both the extent of differentiation induction and viability depended on the cell density, suggesting the release of growth and differentiation stimulation substances into culture supernatant. Higher concentrations of SE partially reduced the Aβ
conclusionHormetic growth stimulation and inhibition of aggregation may be involved in the neuroprotective activity of SE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.