Trial reportJournal of the American Heart Association2018
Diastolic Blood Pressure and Adverse Outcomes in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial.
Trial report in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.Nutrients · 2022Trial
- Influence of polypharmacy on patients with heart failure with preserved ejection fraction: a retrospective analysis on adverse outcomes in the TOPCAT trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Trial
- Associations of Left Ventricular Structure and Function With Blood Pressure in Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.Journal of the American Heart Association · 2020Trial
- Endothelial Activation and Stress Index (EASIX) in coronary artery disease: promising biomarker or oversimplified measure?Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Heart failure with preserved ejection fraction.Nature reviews. Disease primers · 2024Review
- Expert consensus on blood pressure management in critically ill patients.Journal of intensive medicine · 2023Article
- Article
- Associations of short- and long-term mortality with admission blood pressure in Chinese patients with different heart failure subtypes.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Heart failure ejection fraction class conversions: impact of biomarkers, co-morbidities, and pharmacotherapy.ESC heart failure · 2022Article
- Exercise Blood Pressure in Heart Failure With Preserved and Reduced Ejection Fraction.JACC. Heart failure · 2022Article
- Prognostic Value of Right Ventricular Strains Using Novel Three-Dimensional Analytical Software in Patients With Cardiac Disease.Frontiers in cardiovascular medicine · 2022Article
- Presence of physical symptoms in healthy adolescence found to be associated with female gender, obesity, tachycardia, diastolic hypertension and smoking.American journal of cardiovascular disease · 2022Article
- Time-to-event prediction analysis of patients with chronic heart failure comorbid with atrial fibrillation: a LightGBM model.BMC cardiovascular disorders · 2021Article
- Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction.Heart and vessels · 2021Article
- Developing an Internally Validated Veterans Affairs Women Cardiovascular Disease Risk Score Using Veterans Affairs National Electronic Health Records.Journal of the American Heart Association · 2021Article
- A novel nomogram to predict all-cause readmission or death risk in Chinese elderly patients with heart failure.ESC heart failure · 2020Article
- Long-term outcome of hypertensive patients with heart failure with mid-range ejection fraction: The significance of blood pressure control.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Dangers of Overly Aggressive Blood Pressure Control.Current cardiology reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough diastolic blood pressure (DBP) is independently associated with an increased risk of adverse cardiovascular outcomes in the general population, it is unclear if a similar relationship exists in patients with heart failure with preserved ejection fraction. METHODS AND
resultsThis analysis included 1703 (mean age, 72±10 years; 50% men; 78% white) patients with heart failure with preserved ejection fraction enrolled in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial from the Americas who were treated for hypertension. Multivariable Cox regression was used to examine the risk of hospitalization for heart failure, death, and cardiovascular death associated with DBP. The relationship between hospitalization for heart failure and DBP was linear, with an increased risk observed with decreasing DBP values (≥90 mm Hg: referent; 80-89 mm Hg: hazard ratio [HR], 1.44; 95% confidence interval [CI], 0.85-2.44; 70-79 mm Hg: HR, 1.18; 95% CI, 0.69-2.01; 60-69 mm Hg: HR, 1.54; 95% CI, 0.90-2.63; <60 mm Hg: HR, 2.12; 95% CI, 1.20-3.74;
conclusionsDBP values ≥90 and <60 mm Hg are associated with a significant risk of adverse outcomes in patients with heart failure with preserved ejection fraction who are treated for hypertension. Further research is needed to determine optimal DBP targets to reduce the risk of adverse events in patients with heart failure with preserved ejection fraction.
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