ArticleApplied and environmental microbiology2018
Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.
Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 113 citations in OpenAlex.
- Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.Nature communications · 2026Article
- Wastewater Metagenomic Surveillance Reveals Socioeconomic Patterns of Pathogen Diversity and Antimicrobial Resistance in Nairobi, Kenya.Antibiotics (Basel, Switzerland) · 2026Article
- Metagenomic Assessment of Full-Scale Wastewater Treatment Plants Identifies Sentinel Antibiotic Resistance Gene Families for Monitoring Reclaimed Wastewater and Treated Sludge.Environmental science & technology · 2026Article
- The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014-2024).One health (Amsterdam, Netherlands) · 2025Article
- Exploring the Relationship Between Farmland Management and Manure-Derived Antibiotic Resistance Genes and Their Prevention and Control Strategies.Antibiotics (Basel, Switzerland) · 2025Review
- Distinct ARG profiles associated with class 1 integrons in municipal and industrial wastewater treatment plants.Environmental science and ecotechnology · 2025Article
- Prevalence and characterization of class I integrons in multidrug-resistant Escherichia coli isolates from humans and food-producing animals in Zhejiang Province, China.BMC microbiology · 2025Article
- The Impact of Wastewater on Antimicrobial Resistance: A Scoping Review of Transmission Pathways and Contributing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- Genomic and Transcriptomic Analyses Reveal Multiple Strategies forFoods (Basel, Switzerland) · 2024Article
- Exposure to benzalkonium chloride disinfectants promotes antibiotic resistance in sewage sludge microbiomes.The Science of the total environment · 2023Article
- Novel insights into genetic characteristics ofFrontiers in microbiology · 2023Article
- Dietary lead modulates the mouse intestinal microbiome: Subacute exposure to lead acetate and lead contaminated soil.Ecotoxicology and environmental safety · 2023Article
- Diverse functional genes harboured in extracellular vesicles from environmental and human microbiota.Journal of extracellular vesicles · 2022Article
- Genomic and Transcriptomic Analysis Reveal Multiple Strategies for the Cadmium Tolerance inFoods (Basel, Switzerland) · 2022Article
- Still rocking in the structural era: A molecular overview of the small multidrug resistance (SMR) transporter family.The Journal of biological chemistry · 2022Review
- Current status and future perspective of antimicrobial-resistant bacteria and resistance genes in animal-breeding environments.The Journal of veterinary medical science · 2022Review
- The Resistome of ESKAPEE Pathogens in Untreated and Treated Wastewater: A Polish Case Study.Biomolecules · 2022Article
- Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome.BMC oral health · 2022Article
- Effects of activated sludge and UV disinfection processes on the bacterial community and antibiotic resistance profile in a municipal wastewater treatment plant.Environmental science and pollution research international · 2022Article
- Metagenomic community composition and resistome analysis in a full-scale cold climate wastewater treatment plant.Environmental microbiome · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integron platform allows the acquisition, expression, and dissemination of antibiotic resistance genes within gene cassettes. Wastewater treatment plants (WWTPs) contain abundant resistance genes; however, knowledge about the impacts of wastewater treatment on integrons and their gene cassettes is limited. In this study, by using clone library analysis and high-throughput sequencing, we investigated the abundance of class 1, 2, and 3 integrons and their corresponding gene cassettes in three urban WWTPs. Our results showed that class 1 integrons were most abundant in WWTPs and that wastewater treatment significantly reduced the abundance of all integrons. The WWTP influents harbored the highest diversity of class 1 integron gene cassettes, whereas class 3 integron gene cassettes exhibited highest diversity in activated sludge. Most of the gene cassette arrays detected in class 1 integrons were novel. Aminoglycoside, beta-lactam, and trimethoprim resistance genes were highly prevalent in class 1 integron gene cassettes, while class 3 integrons mainly carried beta-lactam resistance gene cassettes. A core class 1 integron resistance gene cassette pool persisted during wastewater treatment, implying that these resistance genes could have high potential to spread into environments through WWTPs. These data provide new insights into the impact of wastewater treatment on integron pools and highlight the need for surveillance of resistance genes within both class 1 and 3 integrons.
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