Evidence map›Paper›PMID 29475599›Full record

ArticleVirology2018

New insights about the regulation of Nidovirus subgenomic mRNA synthesis.

Han Di, Ayisha A McIntyre, Margo A Brinton

Abstract read
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Classification, replication, and transcription ofFrontiers in microbiology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. The molecular virology of coronaviruses.The Journal of biological chemistry · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Han DiDepartment of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30303, USA.
Ayisha A McIntyreDepartment of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30303, USA.
Margo A BrintonDepartment of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30303, USA. Electronic address: mbrinton@gsu.edu.

Funding

Development of a new model of viral hemorrhagic fever. R21AI073824 · NIAID · GEORGIA STATE UNIVERSITY · PI BRINTON, MARGO A · 2007 to 2008
$358k
NIAID NIH HHS R21 AI073824
6 · The paper itself

Abstract

The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5' two-thirds and the structural proteins encoded in the 3' third. They also express their 3' region proteins from a nested set of 3' co-terminal subgenomic messenger RNAs (sg mRNAs). Some but not all of the Nidovirus sg mRNAs also have a common 5' leader sequence that is acquired by a discontinuous RNA synthesis mechanism regulated by multiple 3' body transcription regulating sequences (TRSs) and the 5' leader TRS. Initial studies detected a single major body TRS for each 3' sg mRNA with a few alternative functional TRSs reported. The recent application of advanced techniques, such as next generation sequencing and ribosomal profiling, in studies of arteriviruses and coronaviruses has revealed an expanded sg mRNA transcriptome and coding capacity.

Indexed as

Genome, ViralAnimalsGene Expression Regulation, ViralHumansNidoviralesRNA, MessengerRNA, ViralViral ProteinsRNA, MessengerRNA, ViralViral ProteinsArterivirusCoronavirusDiscontinuous RNA synthesisLeader-body junction sequencesNext generation sequencingNidovirusSubgenomic mRNAsTranscription regulatory sequences

Identifiers

PMID29475599
PMCPMC5987246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.