Evidence map›Paper›PMID 29475579›Full record

ArticleTrends in endocrinology and metabolism: TEM2018

Taking Aim at Glycolysis with CDK8 Inhibitors.

Robert P Fisher

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Robert P FisherDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: robert.fisher@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

Chemical Genetics of Transcriptional Regulation by CDKs in Human CellsR01GM104291 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FISHER, ROBERT P · 2014 to 2017
$1.3M
Chemical Genetic Analysis of the Human Cell CycleR01GM105773 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FISHER, ROBERT P · 2013 to 2016
$1.3M
NIGMS NIH HHS R01 GM104291NIGMS NIH HHS R01 GM105773
6 · The paper itself

Abstract

Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

Indexed as

Cyclin-Dependent Kinase 8GlycolysisPhosphorylationCyclin-Dependent Kinase 8cancerCDK8chemical geneticsglycolysisMediatortranscription

Identifiers

PMID29475579
PMCPMC5911231
OpenAlexW2787966503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.