Evidence map›Paper›PMID 29475550›Full record

ArticleAmerican journal of surgery2018

The negative effect of perioperative red blood cell transfusion on morbidity and mortality after major abdominal operations.

Nathan R Elwood, Allison N Martin, Florence E Turrentine, R Scott Jones, Victor M Zaydfudim

Abstract readMulticenter Study
In one paragraph

Article in American journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Variables affecting mortality rates in patients undergoing emergency abdominal surgery: A retrospective cross-sectional study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023
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  13. Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nathan R ElwoodDepartment of Surgery, University of Virginia, Charlottesville, VA, USA.
Allison N MartinDepartment of Surgery, University of Virginia, Charlottesville, VA, USA.
Florence E TurrentineDepartment of Surgery, University of Virginia, Charlottesville, VA, USA; Surgery Outcomes Research Center, University of Virginia, Charlottesville, VA, USA.
R Scott JonesDepartment of Surgery, University of Virginia, Charlottesville, VA, USA; Surgery Outcomes Research Center, University of Virginia, Charlottesville, VA, USA.
Victor M ZaydfudimDepartment of Surgery, University of Virginia, Charlottesville, VA, USA; Surgery Outcomes Research Center, University of Virginia, Charlottesville, VA, USA; Division of Surgical Oncology, University of Virginia, Charlottesville, VA, USA. Electronic address: vz8h@virginia.edu.
University of Virginia · US

Funding

Postdoctoral Training Grant for MDs in Surgical Oncology ResearchT32CA163177 · NCI · UNIVERSITY OF VIRGINIA · PI Craig Lee Slingluff, Allan Tsung · 2011 to 2026
$4.6M
NCI NIH HHS L30 CA220861NCI NIH HHS T32 CA163177
6 · The paper itself

Abstract

backgroundThis study aims to test associations between perioperative blood transfusion and postoperative morbidity and mortality after major abdominal operations.

methodsThe 2014 ACS NSQIP dataset was queried for all patients who underwent one of the ten major abdominal operations. Separate multivariable regression models, were developed to evaluate the independent effects of perioperative blood transfusion on morbidity and mortality.

resultsOf 48,854 patients in the study cohort, 4887 (10%) received a blood transfusion. Rates of transfusion ranged from 4% for laparoscopic gastrointestinal resection to 58% for open AAA. After adjusting for significant effects of NSQIP-estimated probabilities, transfusion was independently associated with morbidity and mortality after open AAA repair (OR = 1.99/14.4 respectively, p ≤ 0.010), esophagectomy (OR = 2.80/3.0, p < 0.001), pancreatectomy (OR = 1.88/3.01, p < 0.001), hepatectomy (OR = 2.82/5.78, p < 0.001), colectomy (OR = 2.15/3.17, p < 0.001), small bowel resection (OR = 2.81/3.83, p ≤ 0.004), and laparoscopic gastrointestinal operations (OR = 2.73/4.05, p < 0.001).

conclusionsPerioperative blood transfusion is independently associated with an increased risk of morbidity and mortality after most major abdominal operations.

Indexed as

Digestive System Surgical ProceduresAgedErythrocyte TransfusionFemaleHumansIncidenceMaleMiddle AgedMorbidityPerioperative CarePostoperative ComplicationsRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateUnited StatesAbdominal surgeryBlood transfusionMorbidityMortalitySurgical outcomes

Identifiers

PMID29475550
PMCPMC6097952
OpenAlexW2789870653

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.