Evidence map›Paper›PMID 29475386›Full record

ArticleArtificial cells, nanomedicine, and biotechnology2018

Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation.

Karthik Yadav Janga, Akshaya Tatke, Sai Prachetan Balguri, Surya P Lamichanne, Mohamed Moustafa Ibrahim, Doaa Nabih Maria, Monica M Jablonski, Soumyajit Majumdar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial cells, nanomedicine, and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 89 citations in OpenAlex.

  1. Trial
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  5. Article
  6. Article
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  8. Article
  9. Review
  10. Nanostructured Lipid Carrier-loadedPharmaceutical nanotechnology · 2025
    Article
  11. Development of Gentamicin Bilosomes LadenAdvanced pharmaceutical bulletin · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Hydrogels for Mucosal Drug Delivery.ACS applied bio materials · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Karthik Yadav Jangaa Department of Pharmaceutics and Drug Delivery, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
Akshaya Tatkea Department of Pharmaceutics and Drug Delivery, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
Sai Prachetan Balguria Department of Pharmaceutics and Drug Delivery, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
Surya P Lamichannea Department of Pharmaceutics and Drug Delivery, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
Mohamed Moustafa Ibrahimb Department of Ophthalmology , The University of Tennessee Health Science Center, Hamilton Eye Institute , Memphis , TN , USA.
Doaa Nabih Mariab Department of Ophthalmology , The University of Tennessee Health Science Center, Hamilton Eye Institute , Memphis , TN , USA.
Monica M Jablonskib Department of Ophthalmology , The University of Tennessee Health Science Center, Hamilton Eye Institute , Memphis , TN , USA.
Soumyajit Majumdara Department of Pharmaceutics and Drug Delivery, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
University of Mississippi · USThe California Eye Institute · USMansoura University · EG

Funding

Evaluation and Inhibition of Efflux Pumps Expressed on the Blood Ocular BarrierR01EY022120 · NEI · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2015 to 2018
$1.5M
NEI NIH HHS R01 EY022120
6 · The paper itself

Abstract

Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered by short precorneal residence and limited transmembrane permeability of topically administered drugs. Hence, the current study was undertaken to fabricate the ion-sensitive in situ gels of natamycin (NT) bilosomes (NB) for efficient ocular delivery. The effect of cholesterol and sodium taurocholate proportion on the properties of the bilosomes were studied and the formulation with better physicochemical properties was optimized and utilized to derive the in situ gelling system (IG). The impact of type/composition of gelling agent on the formation and characteristics of the hydrogel was investigated. The hydrogel formed from IG with 0.3% w/v gellan gum showed optimal viscoelastic and adhesive characteristics. The ocular safety and cytocompatibility of NB and its IG was confirmed by corneal histology and in vitro cytotoxicity evaluation. A 6- to 9-fold enhancement in the transcorneal flux of NB demonstrated efficient ocular penetration of bilosomes. Moreover, the superior mean dose normalized NT levels in the ocular tissues of rabbits treated with optimized NB and IG illustrated the effectiveness of bilosomes loaded ion-sensitive in situ hydrogels as a potential platform for the improved and prolonged ocular pharmacotherapy.

Indexed as

Administration, OphthalmicBile Acids and SaltsCell LineCorneaHydrogelsLiposomesNatamycinParticle SizePermeabilityRheologyBile Acids and SaltsHydrogelsLiposomesNatamycinbilosome gelscorneal histologyhuman corneal limbal epithelial cell cytotoxicityNatamycinocular dispositionocular drug deliverytranscorneal flux

Identifiers

PMID29475386
PMCPMC6148389
OpenAlexW2787975405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.