Evidence map›Paper›PMID 29474989›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2018

Proportion of adult community-acquired pneumonia cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016.

Ali AlBarrak, Badriah Alotaibi, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Yassein Seedahmed, Mohamed Alshaer, Abdulaziz Altaweel, Husameddin Elshiekh, Abdulhafiz Turkistani and 3 more

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Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Infectious Diseases and Mass Gatherings.Current infectious disease reports · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ali AlBarrakPrince Sultan Military Medical City, Riyadh, Saudi Arabia.
Badriah AlotaibiGlobal Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Yara YassinGlobal Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Abdulaziz MushiGlobal Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Fuad MaashiGlobal Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Yassein SeedahmedGeneral Directorate of Health Affairs in Makkah Region, Makkah, Saudi Arabia.
Mohamed AlshaerGeneral Directorate of Health Affairs in Makkah Region, Makkah, Saudi Arabia.
Abdulaziz AltaweelKing Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Husameddin ElshiekhGeneral Directorate of Health Affairs in Medina Region, Medina, Saudi Arabia.
Abdulhafiz TurkistaniHoly Makkah Municipality, Makkah, Saudi Arabia.
Tanaz PetigaraMerck & Co., Inc., Kenilworth, NJ, USA.
John GrabensteinMerck & Co., Inc., Kenilworth, NJ, USA.
Saber YezliGlobal Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: SYezli@moh.gov.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Hajj mass gathering is a risk for pneumococcal disease. This study was performed to evaluate the proportion of adult community-acquired pneumonia (CAP) cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016. To add sensitivity to etiological attribution, a urine antigen test was used in addition to culture-based methods.

methodsAdult subjects hospitalized with X-ray-confirmed CAP were enrolled prospectively from all general hospitals designated to treat Hajj pilgrims in the holy cities of Mecca and Medina. Patients were treated according to local standard of care and administered the BinaxNow S. pneumoniae urine antigen test.

resultsFrom August 23 to September 23, 2016, a total of 266 patients with CAP were enrolled in the study, 70.6% of whom were admitted to hospitals in Mecca; 53% of the cases were admitted after the peak of Hajj. Patients originated from 43 countries. Their mean age was 65.3 years and the male to female ratio was 2:1. Just over 36% of the cases had diabetes, 10% declared that they were smokers, and 45.4% of cases were treated in the intensive care unit (ICU). The overall case-fatality rate was 10.1%, but was higher among those treated in the ICU and in those with invasive disease. The proportion of CAP cases positive for S. pneumoniae, based on culture or urine antigen test, was 18.0% (95% confidence interval 13.9-23.1%).

conclusionsCAP during Hajj has an important clinical impact. A proportion of CAP cases among Hajj pilgrims were attributable to S. pneumoniae, a pathogen for which vaccines are available. Additional studies to determine the serotypes causing pneumococcal disease could further inform vaccine policy for Hajj pilgrims.

Indexed as

IslamAdultAgedAnniversaries and Special EventsAntigens, BacterialCommunity-Acquired InfectionsFemaleHospitalizationHumansIncidenceMaleMiddle AgedPneumococcal InfectionsProspective StudiesSaudi ArabiaStreptococcus pneumoniaeAntigens, BacterialCommunity-acquired pneumoniaHajjPneumococcal diseaseStreptococcus pneumoniaeVaccine

Identifiers

PMID29474989
PMCPMC7110457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.