ArticleRespiratory physiology & neurobiology2018
GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
Article in Respiratory physiology & neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The central regulatory network of cough: a cornerstone of cough management.Journal of thoracic disease · 2025Review
- Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs-fMRI study.Thoracic cancer · 2023Article
- The influence of CORespiratory physiology & neurobiology · 2023Article
- Optogenetic stimulation of pre-Bötzinger complex reveals novel circuit interactions in swallowing-breathing coordination.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evidence for AlphaThe Journal of pharmacology and experimental therapeutics · 2022Article
- The role of neuronal excitation and inhibition in the pre-Bötzinger complex on the cough reflex in the cat.Journal of neurophysiology · 2022Article
- Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.PloS one · 2021Article
- Connection Input Mapping and 3D Reconstruction of the Brainstem and Spinal Cord Projections to the CSF-Contacting Nucleus.Frontiers in neural circuits · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 ± 4 nl), 1 mM baclofen (64 ± 4 nl) and unilateral microinjections of 0.5 mM muscimol (33 ± 1 nl) in the rNTS significantly reduced cough number (CN), amplitudes of ABD EMGs, expiratory EP, and prolonged the duration of the cough inspiratory phase. GABA microinjections decreased the amplitudes of cough-related DIA EMGs and inspiratory EP; muscimol microinjections decreased the cough DIA EMG on the contralateral side. Only microinjections of GABA into the cNTS suppressed CN. In some cases, microinjections prolonged the inspiratory phase, lowered respiratory rate, changed the depth of breathing, and increased blood pressure and heart rate. Our results confirm that GABA-ergic inhibitory mechanisms in the rNTS can regulate coughing in the anesthetized cat.
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