Evidence map›Paper›PMID 29474507›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2018

PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers.

Bhanu Prakash Kolla, Terry D Schneekloth, Joanna Biernacka, Vijay Shah, Konstantinos N Lazaridis, Jennifer Geske, Victor Karpyak

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bhanu Prakash KollaDepartment of Psychiatry and Psychology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Terry D SchneeklothDepartment of Psychiatry and Psychology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Joanna BiernackaDepartment of Psychiatry and Psychology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Vijay ShahDivision of Gastroenterology and Hepatology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Konstantinos N LazaridisDivision of Gastroenterology and Hepatology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Jennifer GeskeDepartment of Biostatistics, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Victor KarpyakDepartment of Psychiatry and Psychology, Mayo Clinic, 2nd Street SW, Rochester, MN, USA.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

TREAT-MayoU01AA021788 · NIAAA · MAYO CLINIC ROCHESTER · PI MALHI, HARMEET, SHAH, VIJAY H. · 2012 to 2022
$4.7M
NIAAA NIH HHS U01 AA021788
6 · The paper itself

Abstract

aimsPrior studies have established variation at the PNPLA3 gene to be associated with a risk of developing alcoholic liver disease (ALD). We attempt to replicate this finding and other potential genetic variations previously associated with ALD utilizing a case-control design in a cohort of subjects with alcohol use disorders. SHORT SUMMARY: This case-control study performed in a US clinical sample of heavy drinkers, replicates the previously reported association between ALD and rs738409 polymorphism in the PNPLA3 gene in heavy drinkers. This association persisted after accounting for the subject's diabetes status.

methodsPatients of European ancestry with a history of ALD were identified (n = 169). Controls consisted of patients without ALD who were from the same cohorts and were ≥ 30 years of age, had lifetime total years drinking ≥20 and lifetime maximum drinks per day ≥12 (n = 259). Patients were genotyped for 40 candidate single nucleotide polymorphisms (SNPs) selected for the purpose of testing their association with ALD. The association of each SNP with ALD was tested using a logistic regression model, assuming log-additive allele effects. Bonferroni correction was applied and multivariable logistic regression models were used to account for relevant covariates.

resultsAge, sex, and body mass index (BMI) distributions were similar between cases and controls. Diabetes was more prevalent in the ALD cases. Three SNPs were associated with ALD at the nominal significance level (rs738409 in PNPLA3, P = 0.00029; rs3741559 in AQP2, P = 0.0185; rs4290029 in NVL, P = 0.0192); only PNPLA3 rs738409 SNP was significant at the Bonferroni-corrected P-value threshold of 0.00125. Association results remained significant after adjustment for diabetes status.

conclusionOur case-control study confirmed that PNPLA3 rs738409 SNP is associated with ALD. This is an important replication in a US clinical sample with control subjects who had long histories of alcohol consumption.

Indexed as

AcyltransferasesAdultAlcoholismCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansLipaseLiver Diseases, AlcoholicMaleMembrane ProteinsMiddle AgedPhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideWhite PeopleAcyltransferasesLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, human

Identifiers

PMID29474507
PMCPMC6016697
OpenAlexW2791614605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.