ArticlePloS one2018
Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Interleukin-8 and other neutrophil-related biomarkers are associated with 1-year mortality in patients with acute myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Biomarkers of Coagulation Disorders-Where to from Here?Biomolecules · 2026Review
- Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Development of a Clonal and High-Yield Mammalian Cell Line for the Manufacturing of a Hyperactive Human DNase I with Extended Plasma Half-Life Using PASylationPharmaceutics · 2024Article
- Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy.Frontiers in immunology · 2023Review
- Physical Exercise Promotes DNase Activity Enhancing the Capacity to Degrade Neutrophil Extracellular Traps.Biomedicines · 2022Article
- Cell-Free Double-Stranded DNA to DNase Ratio Predicts Outcome after Primary Survived Cardiac Arrest.Cells · 2022Article
- Neutrophil extracellular traps: from physiology to pathology.Cardiovascular research · 2022Review
- Clinical significance of neutrophil extracellular traps biomarkers in thrombosis.Thrombosis journal · 2022Review
- Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk.Thrombosis and haemostasis · 2022Article
- DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross-Sectional Study in Mice and Humans.Journal of the American Heart Association · 2022Article
- Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis.Handbook of experimental pharmacology · 2022Article
- Neutrophil activation and circulating neutrophil extracellular traps are increased in venous thromboembolism patients for at least one year after the clinical event.Journal of thrombosis and thrombolysis · 2022Article
- Autoimmunity roots of the thrombotic events after COVID-19 vaccination.Autoimmunity reviews · 2021Review
- Persistent endotheliopathy in the pathogenesis of long COVID syndrome.Journal of thrombosis and haemostasis : JTH · 2021Article
- Review
- Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction.Basic research in cardiology · 2021Article
- The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis.International journal of molecular sciences · 2021Review
- The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis.Frontiers in cardiovascular medicine · 2021Review
- Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVenous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.
objectivesWe analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.
methodsWe quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute VTE of a prospective cohort study (SWITCO65+).
resultsLevels of ceDNA and nucleosomes, but not NETs, correlated with VTE extent. Infectious comorbidities independently increased ceDNA levels in VTE. CeDNA strongly correlated with C-reactive protein and leukocytosis, suggesting an association of ceDNA with inflammation in VTE patients. CeDNA furthermore predicted PE-related and all-cause mortality, but not VTE recurrence, during a 3-year follow-up.
conclusionsOur study suggests that ceDNA levels in VTE patients reflect the degree of inflammation and may serve as a biomarker to stratify VTE patients at risk for mortality.
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