ArticleeLife2018
Haploinsufficiency of
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms.Cell biology and toxicology · 2023Article
- SIRT7 and p53 interaction in embryonic development and tumorigenesis.Frontiers in cell and developmental biology · 2023Article
- The roles of sirtuins in ferroptosis.Frontiers in physiology · 2023Review
- SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases.Aging and disease · 2022Review
- Article
- Nuclear NADScience advances · 2021Article
- SIRT6 Through the Brain Evolution, Development, and Aging.Frontiers in aging neuroscience · 2021Article
- The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.Nucleic acids research · 2020Article
- Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.Journal of proteome research · 2020Article
- Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.Frontiers in pharmacology · 2020Article
- The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells.Frontiers in endocrinology · 2020Article
- SIRT6, a Mammalian Deacylase with Multitasking Abilities.Physiological reviews · 2020Review
- Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1).Aging cell · 2019Article
- Updates on the epigenetic roles of sirtuins.Current opinion in chemical biology · 2019Review
- SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis.Cell death & disease · 2018Article
- Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.Differentiation; research in biological diversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian sirtuin 6 (Sirt6) is a conserved NAD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.