Evidence map›Paper›PMID 29474060›Full record

ArticleACS nano2018

Probing DNA Translocations with Inplane Current Signals in a Graphene Nanoribbon with a Nanopore.

Stephanie J Heerema, Leonardo Vicarelli, Sergii Pud, Raymond N Schouten, Henny W Zandbergen, Cees Dekker

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Review
  3. Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Graphene Nanopore Fabrication and Applications.International journal of molecular sciences · 2025
    Review
  6. The Road Toward Nanopore Sequencing of Glycosaminoglycans.Handbook of experimental pharmacology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie J HeeremaKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.
Leonardo VicarelliKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.
Sergii PudKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.ORCID 0000-0002-1393-9135
Raymond N SchoutenKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.
Henny W ZandbergenKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.
Cees DekkerKavli Institute of Nanoscience Delft, Delft University of Technology , Van der Maasweg 9 , 2629 HZ Delft , The Netherlands.ORCID 0000-0001-6273-071X

Funding

Plasmonic nanopores for trapping, controlled motion and sequencing of DNAR01HG007406 · NHGRI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AKSIMENTIEV, ALEKSEI · 2013 to 2016
$2.4M
NHGRI NIH HHS R01 HG007406
6 · The paper itself

Abstract

Many theoretical studies predict that DNA sequencing should be feasible by monitoring the transverse current through a graphene nanoribbon while a DNA molecule translocates through a nanopore in that ribbon. Such a readout would benefit from the special transport properties of graphene, provide ultimate spatial resolution because of the single-atom layer thickness of graphene, and facilitate high-bandwidth measurements. Previous experimental attempts to measure such transverse inplane signals were however dominated by a trivial capacitive response. Here, we explore the feasibility of the approach using a custom-made differential current amplifier that discriminates between the capacitive current signal and the resistive response in the graphene. We fabricate well-defined short and narrow (30 nm × 30 nm) nanoribbons with a 5 nm nanopore in graphene with a high-temperature scanning transmission electron microscope to retain the crystallinity and sensitivity of the graphene. We show that, indeed, resistive modulations can be observed in the graphene current due to DNA translocation through the nanopore, thus demonstrating that DNA sensing with inplane currents in graphene nanostructures is possible. The approach is however exceedingly challenging due to low yields in device fabrication connected to the complex multistep device layout.

Indexed as

NanoporesDNAElectric ConductivityElectrochemical TechniquesEquipment DesignGraphiteMotionNanostructuresNanotechnologySequence Analysis, DNADNAGraphitebiosensingDNA sequencinggraphene nanoribbonnanoporeSTEM

Identifiers

PMID29474060
PMCPMC5876620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.