Evidence map›Paper›PMID 29473908›Full record

Trial reportNutrients2018

l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function.

Angelika K Sawicka, Dace Hartmane, Patrycja Lipinska, Ewa Wojtowicz, Wieslawa Lysiak-Szydlowska, Robert A Olek

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  3. The bright and the dark sides of L-carnitine supplementation: a systematic review.Journal of the International Society of Sports Nutrition · 2020
    Pooled it
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  15. l-carnitine: Nutrition, pathology, and health benefits.Saudi journal of biological sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Angelika K SawickaDepartment of Bioenergetics and Nutrition, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. angelika.sawicka@awf.gda.pl.
Dace HartmaneLatvian Institute of Organic Synthesis, LV-1006 Riga, Latvia. dace_hartmane@osi.lv.
Patrycja LipinskaInstitute of Physical Culture, Kazimierz Wielki University, 85-091 Bydgoszcz, Poland. patrycja.lipinska@ukw.edu.pl.
Ewa WojtowiczDepartment of Anatomy and Anthropology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. ewawoj14@wp.pl.
Wieslawa Lysiak-SzydlowskaDepartment of Health Sciences, Powislanski College, 82-500 Kwidzyn, Poland. wlysiak@onet.pl.
Robert A OlekDepartment of Bioenergetics and Nutrition, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. robol@awf.gda.pl.ORCID 0000-0002-3714-7386
Gdansk University of Physical Education and Sport · PLKazimierz Wielki University in Bydgoszcz · PLLatvijas Organiskās Sintēzes Institūts · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle wasting, associated with aging, may be regulated by the inflammatory cytokines as well as by insulin-like growth factor 1 (IGF-1). l-carnitine possesses anti-inflammatory properties and increases plasma IGF-1 concentration, leading to the regulation of the genes responsible for protein catabolism and anabolism. The purpose of the present study was to evaluate the effect of a 24-week l-carnitine supplementation on serum inflammatory markers, IGF-1, body composition and skeletal muscle strength in healthy human subjects over 65 years of age. Women between 65 and 70 years of age were supplemented for 24 weeks with either 1500 mg l-carnitine-l-tartrate or an isonitrogenous placebo per day in a double-blind fashion. Before and after the supplementation protocol, body mass and composition, as well as knee extensor and flexor muscle strength were determined. In the blood samples, free carnitine, interleukin-6, tumor necrosis factor-α, C-reactive protein and IGF-1 were determined. A marked increase in free plasma carnitine concentration was observed due to l-carnitine supplementation. No substantial changes in other parameters were noted. In the current study, supplementation for 24 weeks affected neither the skeletal muscle strength nor circulating markers in healthy women over 65 years of age. Positive and negative aspects of l-carnitine supplementation need to be clarified.

Indexed as

AgedAnti-Inflammatory AgentsBiomarkersBody CompositionBody Mass IndexCarnitineC-Reactive ProteinDietary SupplementsDouble-Blind MethodFemaleHumansInsulin-Like Growth Factor IInterleukin-6Muscle, SkeletalMuscle StrengthPilot ProjectsAnti-Inflammatory AgentsBiomarkersCarnitineC-Reactive ProteinIGF1 protein, humanIL6 protein, humanInsulin-Like Growth Factor IInterleukin-6Tumor Necrosis Factor-alphabody compositioncytokinesmuscle strengthsarcopenia

Identifiers

PMID29473908
PMCPMC5852831
OpenAlexW2791466668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.