Evidence map›Paper›PMID 29473167›Full record

ArticleThe Journal of comparative neurology2018

Efferent projections of excitatory and inhibitory preBötzinger Complex neurons.

Cindy F Yang, Jack L Feldman

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Trial
  2. Article
  3. Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Article
  9. Insular routing to orbitofrontal cortex enables breathing awareness.medRxiv : the preprint server for health sciences · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Leveraging GPT-4o for Automated Extraction of Neural Projections from Scientific Literature.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
    Article
  19. Article
  20. A Dynamic Link between Respiration and Arousal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cindy F YangDepartment of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, California, 90095-1763.ORCID 0000-0001-6144-4658
Jack L FeldmanDepartment of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, California, 90095-1763.ORCID 0000-0003-3692-9412

Funding

Neural control of breathingR35HL135779 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2017 to 2023
$5.6M
Functional Dissection of Medullary Respiratory MicrocircuitsR01NS072211 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2010 to 2020
$3.8M
Neural basis for positive effects of breathing on emotional stateR21AT009034 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2018 to 2019
$428k
Genetic mapping of neural circuits that control breathingF32HL126522 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, CINDY · 2015 to 2016
$112k
NCCIH NIH HHS R21 AT009034NHLBI NIH HHS F32 HL126522NHLBI NIH HHS R35 HL135779NINDS NIH HHS R01 NS072211
6 · The paper itself

Abstract

The preBötzinger Complex (preBötC), a compact medullary region essential for generating normal breathing rhythm and pattern, is the kernel of the breathing central pattern generator (CPG). Excitatory preBötC neurons in rats project to major breathing-related brainstem regions. Here, we provide a brainstem connectivity map in mice for both excitatory and inhibitory preBötC neurons. Using a genetic strategy to label preBötC neurons, we confirmed extensive projections of preBötC excitatory neurons within the brainstem breathing CPG including the contralateral preBötC, Bötzinger Complex (BötC), ventral respiratory group, nucleus of the solitary tract, parahypoglossal nucleus, parafacial region (RTN/pFRG or alternatively, pF

Indexed as

AnimalsCholine O-AcetyltransferaseEfferent PathwaysForkhead Transcription FactorsGlycine Plasma Membrane Transport ProteinsGreen Fluorescent ProteinsMaleMiceMice, TransgenicNeural InhibitionNeuronsPhosphopyruvate HydrataseProsencephalonRepressor ProteinsRespiratory CenterSomatostatinCholine O-Acetyltransferaseenhanced green fluorescent proteinForkhead Transcription FactorsFoxp2 protein, mouseGlycine Plasma Membrane Transport ProteinsGreen Fluorescent ProteinsPhosphopyruvate HydrataseRepressor ProteinsSlc6a5 protein, mouseSomatostatinbreathingneural circuitpreBötzinger ComplexrespirationRRID: AB_10000240RRID: AB_2079751RRID: AB_2107133RRID: AB_2298772RRID: AB_518614RRID: IMSR_JAX:007914RRID: IMSR_JAX:013044RRID: IMSR_RBRC04708RRID:SCR_002978RRID: SCR_003070NIH

Identifiers

PMID29473167
PMCPMC5869167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.