ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018
Relationship among symptom clusters, quality of life, and treatment-specific optimism in patients with cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Symptom clusters in patients receiving chemotherapy: A systematic review.BMJ supportive & palliative care · 2022Pooled it
- Reflexology and meditative practices for symptom management among people with cancer: Results from a sequential multiple assignment randomized trial.Research in nursing & health · 2021Trial
- Psychological Resources in Adults with Cancer: A Systematic Review of Quantitative Studies.Cancers · 2026Review
- Phase III Trial: Single Low-Dose 5 mg Dexamethasone with NEPA for Preventing 168 h Nausea and Vomiting of Diverse Highly or Moderately Emetogenic Chemotherapy (LD-NEPA).Diseases (Basel, Switzerland) · 2026Article
- Global research trends and hotspots in breast cancer related fatigue: a bibliometric investigation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Differences in symptom experiences and coping strategies based on post-traumatic growth and depreciation in cancer patients undergoing chemotherapy: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Medical and psychosocial symptom clusters and their temporal patterns in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Exploring the relationship between postoperative psychological resilience and symptom burden in esophageal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Efficacy of single low-dose dexamethasone with NEPA for the 168 h prevention of highly or moderately emetogenic chemotherapy.Frontiers in pharmacology · 2025Article
- The effect of positive mental well-being on patient reported outcome (PRO): finding from a cross-sectional multi-disease study in China.Health and quality of life outcomes · 2024Article
- Exploring the symptoms and psychological experiences among lung cancer convalescence patients after radical lobectomy: A qualitative study.Cancer medicine · 2024Article
- 2020 ASCO, 2023 NCCN, 2023 MASCC/ESMO, and 2019 CCO: a comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Symptoms experienced after transcatheter arterial chemoembolization in patients with primary liver cancer: A network analysis.Asia-Pacific journal of oncology nursing · 2024Article
- The increasing role of the allergist in the management of infusion reactions at the Oncology Infusion Center.Frontiers in allergy · 2024Article
- Symptom clusters in breast cancer survivors with and without type 2 diabetes over the cancer trajectory.Asia-Pacific journal of oncology nursing · 2024Article
- Frequency and burden of potentially treatable symptoms in glioma patients with stable disease.Heliyon · 2023Article
- Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy.Biological research for nursing · 2023Article
- Enhanced supportive care for advanced cancer patients: study protocol for a randomized controlled trial.BMC nursing · 2022Article
- Positive Psychology Approaches to Interventions for Cancer Dyads: A Scoping Review.International journal of environmental research and public health · 2022Article
- Symptom clusters in outpatients with cancer using different dimensions of the symptom experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is increasing evidence that disease and therapy-related symptoms frequently co-occur in so-called symptom clusters (SCs), which may significantly impair quality of life in patients with cancer. Although psychosocial resources may play pivotal roles in maintaining or improving quality of life, they have been neglected in SC research. Therefore, we aim to identify SCs and their relative impact on quality of life when psychosocial resources are accounted for.
methodsPatients with cancer (n = 304) undergoing chemotherapy or chemo-radiation therapy participated in a cross-sectional survey consisting of measures assessing symptoms, quality of life, resilience, treatment-specific optimism (TSO), and social support. Exploratory factor analyses and multiple regression analyses were used to identify SCs and significant explanatory variables of overall quality of life.
resultsFatigue-pain, anxiety-depression, cancer therapy-related toxicity, and nausea-vomiting clusters were identified. In our final model, the fatigue-pain cluster (β = - 0.41, p < 0.001), nausea-vomiting cluster (β = - 0.28, p < 0.001), TSO (β = 0.21, p < 0.001), and receiving chemo-radiation treatment (β = - 0.11, p = 0.03) accounted for 44% of variance in overall quality of life. However, the identified SCs explained quality of life in patients with varying levels of TSO to a different extent.
conclusionsOur findings indicate that the TSO of patients may be a major factor to consider in managing SCs, because-depending on its level-different SCs and even clusters encompassing comparatively less distressing symptoms (i.e., cancer therapy-related toxicities) may strongly affect quality of life.
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