ArticleCentral-European journal of immunology2017
Presence of a single nucleotide polymorphism (RS3758581) in a boy with DRESS syndrome.
Article in Central-European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.Acta bio-medica : Atenei Parmensis · 2019Review
- The role of pharmacogenetics of cytochrome P450s in phenytoin-induced DRESS syndrome.Central-European journal of immunology · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, potentially life-threatening, drug-induced hypersensitivity reaction that includes rash, hematologic abnormalities, lymphadenopathy, and internal organ involvement. The pathogenesis of DRESS syndrome is partially understood. Various medications have been described as the cause of DRESS syndrome. Phenytoin and allopurinol are the most commonly reported culprit drugs, although more than 50 drugs can induce DRESS syndrome. Members of the cytochrome P450 (CYP) superfamily are the most commonly involved enzymes in metabolism of drugs such as phenytoin. This case report addresses the influence of CYP2C9 genetic polymorphism (a single nucleotide polymorphism) on phenytoin drug metabolism, thereby causing DRESS syndrome.
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