Evidence map›Paper›PMID 29472716›Full record

ArticleCell death and differentiation2018

PD-1 is required to maintain stem cell properties in human dental pulp stem cells.

Yao Liu, Huan Jing, Xiaoxing Kou, Chider Chen, Dawei Liu, Yan Jin, Li Lu, Songtao Shi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yao LiuDepartment of Pediatric Dentistry, School of Stomatology, China Medical University, Shenyang, 110002, China.
Huan JingDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, PA, Philadelphia, 19104, USA.
Xiaoxing KouDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, PA, Philadelphia, 19104, USA.
Chider ChenDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, PA, Philadelphia, 19104, USA.
Dawei LiuDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, PA, Philadelphia, 19104, USA.
Yan JinState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Li LuDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, 110002, Shenyang, China. luli@mail.cmu.edu.cn.
Songtao ShiDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, PA, Philadelphia, 19104, USA. songtaos@dental.upenn.edu.
University of Pennsylvania · USAir Force Medical University · CNChina Medical University · CN

Funding

OSTEOGENIC MECHANISMS OF SHEDR01DE017449 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHI, SONGTAO · 2007 to 2017
$3.5M
NIDCR NIH HHS R01 DE017449
6 · The paper itself

Abstract

Programmed cell death-1 (PD-1) belongs to an inhibitory signaling pathway capable of maintaining central and peripheral immune tolerance. Blockage of PD-1 has been identified as a promising immunotherapeutic approach for cancer and chronic infectious diseases. However, it is unknown whether PD-1 pathway regulates stem cell function. It is generally believed that mesenchymal stem cells (MSCs) produce PD-1 ligand, but fail to express PD-1. In this study, we show that neural crest-derived MSCs from dental pulp (MSC-DP), but not MSCs from bone marrow, expressed PD-1. Knocking down PD-1 expression in MSC-DP results in a significantly reduced capacity for cell proliferation and accelerated multipotential differentiation. Mechanistically, we show that PD-1 regulates a SHP2/ERK/Notch cascade to maintain proliferation and a SHP2/ERK/β-catenin cascade to inhibit osteo-/odontogenic differentiation. This study indicates that PD-1 is a key surface molecule controlling cell proliferation and multipotential differentiation of MSC-DP. Through regulating PD-1/SHP2/ERK signaling, we can significantly improve the quality and quantity of culture-expanded MSC-DP for potential clinical therapies.

Indexed as

Cell DifferentiationCell ProliferationSignal TransductionAnimalsDental PulpHumansMesenchymal Stem CellsMiceMice, NudeProgrammed Cell Death 1 ReceptorPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID29472716
PMCPMC6030052
OpenAlexW2790973556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.