ArticleJournal of exposure science & environmental epidemiology2018
Temporal trends of phthalate exposures during 2007-2010 in Swedish pregnant women.
Article in Journal of exposure science & environmental epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review.Environmental health perspectives · 2024Article
- Management of phthalates in Canada and beyond: can we do better to protect human health?Frontiers in public health · 2024Article
- Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort.Environmental science & technology · 2023Article
- Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth.Molecular psychiatry · 2023Article
- Determinants of phthalate exposures in pregnant women in New York City.Environmental research · 2022Article
- Identification of profiles and determinants of maternal pregnancy urinary biomarkers of phthalates and replacements in the Illinois Kids Development Study.Environment international · 2022Article
- Prenatal phthalate exposure and early childhood wheeze in the SELMA study.Journal of exposure science & environmental epidemiology · 2022Article
- Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Prenatal exposures to mixtures of endocrine disrupting chemicals and children's weight trajectory up to age 5.5 in the SELMA study.Scientific reports · 2021Article
- Associations of prenatal exposure to phthalates with measures of cognition in 7.5-month-old infants.Neurotoxicology · 2021Article
- Prenatal phthalate exposures and executive function in preschool children.Environment international · 2021Article
- Phthalate levels in indoor dust and associations to croup in the SELMA study.Journal of exposure science & environmental epidemiology · 2021Article
- Temporal Trends of Exposure to Phthalates and Phthalate Alternatives in California Pregnant Women during 2007-2013: Comparison with Other Populations.Environmental science & technology · 2020Article
- Determinants and characterization of exposure to phthalates, DEHTP and DINCH among pregnant women in the PROTECT birth cohort in Puerto Rico.Journal of exposure science & environmental epidemiology · 2020Article
- Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort.Journal of exposure science & environmental epidemiology · 2020Article
- Endocrine Disruption and Reproductive Pathology.Toxicologic pathology · 2019Article
- A Novel Approach to Chemical Mixture Risk Assessment-Linking Data from Population-Based Epidemiology and Experimental Animal Tests.Risk analysis : an official publication of the Society for Risk Analysis · 2019Article
- Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans.Scientific reports · 2018Article
- Associations of prenatal phthalate exposure with neurobehavioral outcomes in 4.5- and 7.5-month-old infants.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of "new generation compounds" coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH).
objectivesIn order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007-2010).
methodsWe collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders.
resultsAll 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period.
conclusionsUrinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.
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