ArticleScientific reports2018
The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Social determinants impact both viral infections and brain development.Pediatric research · 2025Review
- Autism Spectrum Disorder: From Experimental Models to Probiotic Application with a Special Focus onNutrients · 2025Review
- Social context as a source of variability in the psychological sciences.Frontiers in human neuroscience · 2024Article
- High Housing Density-Induced Chronic Stress Diminishes Ovarian Reserve via Granulosa Cell Apoptosis by Angiotensin II Overexpression in Mice.International journal of molecular sciences · 2022Article
- Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals.Neurobiology of stress · 2021Article
- Liveable residential space, residential density, and hypertension in Hong Kong: A population-based cohort study.PLoS medicine · 2021Article
- Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility.Brain sciences · 2021Review
- Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021Review
- A bird's-eye view of brain activity in socially interacting mice through mobile edge computing (MEC).Science advances · 2020Article
- Monoamine and genome-wide DNA methylation investigation in behavioral addiction.Scientific reports · 2020Article
- Concurrent and Delayed Behavioral and Monoamine Alterations by Excessive Sucrose Intake in Juvenile Mice.Frontiers in neuroscience · 2020Article
- Living inside the box: environmental effects on mouse models of human disease.Disease models & mechanisms · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population density has been suggested to affect social interactions of individuals, but the underlying neural mechanisms remain unclear. In contrast, neurotransmission of monoamines such as serotonin (5-HT) and dopamine (DA) has been demonstrated to play important roles in social behaviors. Here, we investigated whether housing density affected social interactions of rodents and non-human primates housed in groups, and its correlations with monoamines. Japanese macaques exhibited higher plasma 5-HT, but not DA, concentrations than rhesus macaques. Similarly, C57BL/6 mice exhibited higher plasma and brain tissue 5-HT concentrations than DBA2 mice. Under crowding, C57BL/6 mice and Japanese macaques exhibited more prominent social avoidance with mates than DBA2 mice and rhesus macaques, respectively. Although DBA2 mice and rhesus macaques in crowding exhibited elevated plasma stress hormones, such stress hormone elevations associated with crowding were absent in C57BL/6 mice and Japanese macaques. Administration of parachlorophenylalanine, which inhibits 5-HT synthesis, increased social interactions and stress hormones in C57BL/6 mice under crowding. These results suggest that, animals with hyperserotonemia may exhibit social avoidance as an adaptive behavioral strategy to mitigate stress associated with crowding environments, which may also be relevant to psychiatric disorder such as autism spectrum disorder.
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Registered trials
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