ArticleNature communications2018
Single-molecule theory of enzymatic inhibition.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effects of Chemical Modulators on Enzyme Specificity.The journal of physical chemistry. B · 2026Article
- Peptides Derived From Reactive Center Loops Inhibit Digestive Trypsin-Like Enzymes in Lepidopteran Pests.Archives of insect biochemistry and physiology · 2026Article
- Inhibitory Effects of Bisphenol Z on 11β-Hydroxysteroid Dehydrogenase 1 and In Silico Molecular Docking Analysis.Molecules (Basel, Switzerland) · 2025Article
- Adaptive resetting for informed search strategies and the design of non-equilibrium steady-states.Nature communications · 2025Article
- High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis.Nature communications · 2025Article
- Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P.Nucleic acids research · 2025Article
- Controlling noise with self-organized resetting.Communications physics · 2025Article
- Nonallosteric activation of posttranslational modification enzymes by active site-directed inhibitors.Computational and structural biotechnology journal · 2024Article
- Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model.Journal of enzyme inhibition and medicinal chemistry · 2023Review
- Inhibitory Potential of Synthetic Amino Acid Derivatives against Digestive Enzymes as Promising Hypoglycemic and Anti-Obesity Agents.Biomolecules · 2023Article
- Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase.International journal of tryptophan research : IJTR · 2022Article
- Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries.Chembiochem : a European journal of chemical biology · 2021Article
- Thermostable and organic solvent-tolerant acid pectinase from3 Biotech · 2021Article
- The Kinetic and Analytical Aspects of Enzyme Competitive Inhibition: Sensing of Tyrosinase Inhibitors.Biosensors · 2021Article
- Immobilized Crosslinked Pectinase Preparation on Porous ZSM-5 Zeolites as Reusable Biocatalysts for Ultra-Efficient Hydrolysis of β-Glycosidic Bonds.Frontiers in chemistry · 2021Article
- Combination of network and molecule structure accurately predicts competitive inhibitory interactions.Computational and structural biotechnology journal · 2021Article
- Experimental Realization of Diffusion with Stochastic Resetting.The journal of physical chemistry letters · 2020Article
- Order Through Disorder: The Characteristic Variability of Systems.Frontiers in cell and developmental biology · 2020Review
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The classical theory of enzymatic inhibition takes a deterministic, bulk based approach to quantitatively describe how inhibitors affect the progression of enzymatic reactions. Catalysis at the single-enzyme level is, however, inherently stochastic which could lead to strong deviations from classical predictions. To explore this, we take the single-enzyme perspective and rebuild the theory of enzymatic inhibition from the bottom up. We find that accounting for multi-conformational enzyme structure and intrinsic randomness should strongly change our view on the uncompetitive and mixed modes of inhibition. There, stochastic fluctuations at the single-enzyme level could make inhibitors act as activators; and we state-in terms of experimentally measurable quantities-a mathematical condition for the emergence of this surprising phenomenon. Our findings could explain why certain molecules that inhibit enzymatic activity when substrate concentrations are high, elicit a non-monotonic dose response when substrate concentrations are low.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.