Evidence map›Paper›PMID 29472567›Full record

ArticleNature communications2018

Polyrotaxane-based supramolecular theranostics.

Guocan Yu, Zhen Yang, Xiao Fu, Bryant C Yung, Jie Yang, Zhengwei Mao, Li Shao, Bin Hua, Yijing Liu, Fuwu Zhang and 8 more

Erratum issuedAbstract readEvaluation Study
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Smart Cancer Nanomedicine for Synergetic Therapy.Current medicinal chemistry · 2025
    Review
  7. Review
  8. Fluorinated macromolecular amphiphiles as prototypic molecular drones.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Guocan YuLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Zhen YangLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-4056-0347
Xiao FuLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD, 20892, USA.
Bryant C YungLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Jie YangState Key Laboratory of Chemical Engineering, Centre for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China.
Zhengwei MaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. zwmao@zju.edu.cn.ORCID http://orcid.org/0000-0001-7990-2856
Li ShaoState Key Laboratory of Chemical Engineering, Centre for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China.
Bin HuaState Key Laboratory of Chemical Engineering, Centre for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China.
Yijing LiuLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Fuwu ZhangLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Quli FanKey Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 210023, Nanjing, China. iamqlfan@njupt.edu.cn.ORCID http://orcid.org/0000-0002-9387-0165
Sheng WangLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Orit JacobsonLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Albert JinLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD, 20892, USA.
Changyou GaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Xiaoying TangSchool of Life Science, Beijing Institute of Technology, 100081, Beijing, China.
Feihe HuangState Key Laboratory of Chemical Engineering, Centre for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China. fhuang@zju.edu.cn.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. shawn.chen@nih.gov.ORCID http://orcid.org/0000-0002-9622-0870

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Biomedical Studies and Cellular Imaging via Atomic Force MicroscopyZIAEB000015 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI JIN, ALBERT J · 2009 to 2025
$5.8M
6 · The paper itself

Abstract

The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is of importance for future clinical application. The premature burst release and poor degradation kinetics indicative of polymer-based nanomedicines remain the major obstacles for clinical translation. Herein we prepare theranostic shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane (PDI-PCL-b-PEG-RGD⊃β-CD-NH

Indexed as

AnimalsAntineoplastic Agentsbeta-CyclodextrinsCell Line, TumorCyclodextrinsDoxorubicinDrug Delivery SystemsFemaleHumansMiceMice, Inbred BALB CMice, NudeNanoparticlesNeoplasmsPoloxamerPositron Emission Tomography Computed TomographyAntineoplastic Agentsbeta-CyclodextrinsCyclodextrinsDoxorubicinPoloxamerpolyrotaxaneRotaxanes

Identifiers

PMID29472567
PMCPMC5823937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.