Trial reportJournal of the American Society of Nephrology : JASN2018
Cluster-Randomized Trial of Devices to Prevent Catheter-Related Bloodstream Infection.
Trial report in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02593149 (Product Evaluation for the Effectiveness of the ClearGuard® HD End Cap), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Product Evaluation for the Effectiveness of the ClearGuard® HD End Cap
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Infection Prevention and Control Practices Among United States Hemodialysis Facilities.Kidney international reports · 2026Article
- More than a Last Resort: The Role of Tunneled Catheters in Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Vascular access for hemodialysis and catheter-related bloodstream infections: a survey on preventive measures and treatment strategies by the EPDWG and ESPN Dialysis Working Group.European journal of pediatrics · 2026Article
- Impact of infection prevention and control quality improvements in haemodialysis facilities: a scoping review.BMC nephrology · 2025Article
- Single-center experience on catheter-related sepsis in tunneled central venous catheters in hemodialysis patients.Clinical nephrology · 2025Article
- From Home to Wearable Hemodialysis: Barriers, Progress, and Opportunities.Clinical journal of the American Society of Nephrology : CJASN · 2024Review
- Use of ClearGuard HD caps in pediatric hemodialysis patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Nursing and Supply Chain as Critical Partners in Enterprise-Level Efforts to Prevent Hemodialysis Associated Central Line-Associated Blood Stream Infections: A Case Study.HCA healthcare journal of medicine · 2024Article
- Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial.BMJ open · 2022Article
- Brachial artery transposition versus catheters as tertiary vascular access for maintenance hemodialysis: a single-center retrospective study.Scientific reports · 2022Article
- Biofilm-forming microorganisms causing hospital-acquired infections from intravenous catheter: A systematic review.Current research in microbial sciences · 2022Article
- Evaluating a Novel Hemodialysis Central Venous Catheter Cap in Reducing Bloodstream Infections: A Quality Improvement Initiative.International journal of nephrology and renovascular disease · 2021Article
- Nitric Oxide-Releasing Insert for Disinfecting the Hub Region of Tunnel Dialysis Catheters.ACS applied materials & interfaces · 2020Article
- REDUcing the burden of dialysis Catheter ComplicaTIOns: a National approach (REDUCCTION) - design and baseline results.Kidney360 · 2020Article
- Minimising Blood Stream Infection: Developing New Materials for Intravascular Catheters.Medicines (Basel, Switzerland) · 2020Review
- Novel Approaches to Arteriovenous Access Creation, Maturation, Suitability, and Durability for Dialysis.Kidney international reports · 2020Review
- Tunneled hemodialysis catheter care practices and blood stream infection rate in children: results from the SCOPE collaborative.Pediatric nephrology (Berlin, Germany) · 2020Article
- Targeting Zero Infections in Dialysis: New Devices, Yes, but also Guidelines, Checklists, and a Culture of Safety.Journal of the American Society of Nephrology : JASN · 2018Article
- The Clinical and Economic Value of ClearGuard HD in the Inpatient Setting for Hemodialysis Catheter Management.Journal of infusion nursing : the official publication of the Infusion Nurses SocietyObservational
Corrections and comments
- Commented on by
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central venous catheters (CVCs) contribute disproportionately to bloodstream infection (BSI) and, by extension, to infection-related hospitalization, mortality, and health care costs in patients undergoing dialysis. Recent product advancements may reduce BSIs, but a sufficiently powered comparative-effectiveness study is needed to facilitate evidence-based patient care decisions. In a 13-month, prospective, cluster-randomized, open-label trial, we compared BSI rates in facilities using ClearGuard HD antimicrobial barrier caps (ClearGuard group) with those in facilities using Tego hemodialysis connectors plus Curos disinfecting caps (Tego+Curos group). Forty DaVita dialysis facilities in the United States were pair-matched by BSI rate, number of patients using CVCs, and geographic location, and then cluster randomized 1:1. We enrolled all adult patients undergoing dialysis with CVCs at these facilities, except those allergic to heparin or chlorhexidine. Overall, 1671 patients participated in the study, accruing >183,000 CVC-days. The study outcome was positive blood culture (PBC) rate as an indicator of BSI rate. We calculated results at the cluster level and adjusted for the facility cluster effect. During a 3-month run-in period immediately before study interventions, the groups had similar BSI rates (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.