Evidence map›Paper›PMID 29472382›Full record

ArticleJournal of lipid research2018

Dopamine D2 receptor upregulates leptin and IL-6 in adipocytes.

Xiaoyan Wang, Van Anthony Villar, Andrew Tiu, Kiran K Upadhyay, Santiago Cuevas

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Biological mechanisms of dopamine DFrontiers in endocrinology · 2025
    Article
  5. Glucose sensing and homeostasis by adipocyte GPCR.Frontiers in endocrinology · 2025
    Review
  6. Article
  7. Article
  8. Anti-Inflammatory Effects of Peripheral Dopamine.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Nucleus accumbens cytoarchitecture predicts weight gain in children.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Dopaminergic Pathways in Obesity-Associated Inflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  18. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiaoyan WangDepartment of Medicine, Division of Renal Diseases & Hypertension, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
Van Anthony VillarDepartment of Medicine, Division of Renal Diseases & Hypertension, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
Andrew TiuDepartment of Medicine, Division of Renal Diseases & Hypertension, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
Kiran K UpadhyayDepartment of Pediatrics, Division of Pediatric Nephrology, University of Florida, Gainesville, FL 32607.
Santiago CuevasResearch Center for Genetic Medicine, Children's National Health System, Washington DC 20010. Electronic address: Scg76@hotmail.com.
George Washington University · USChildren's National · USUniversity of Florida · US

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAREY, ROBERT MUNSON · 2004 to 2020
$31.8M
Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
NHLBI NIH HHS P01 HL068686NHLBI NIH HHS P01 HL074940
6 · The paper itself

Abstract

Leptin is a pro-inflammatory cytokine secreted by the adipose tissue. Dopamine D

Indexed as

Up-Regulation3T3-L1 CellsAdipocytesAnimalsCells, CulturedHumansInterleukin-6LeptinMaleMiceMice, Inbred C57BLReceptors, Dopamine D2DRD2 protein, mouseInterleukin-6LeptinReceptors, Dopamine D2adipocytedopamine receptorsinflammation

Identifiers

PMID29472382
PMCPMC5880505
OpenAlexW2787993318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.