ArticleEndocrine connections2018
TAAR1 induces a disturbed GSK3β phosphorylation in recurrent miscarriages through the ODC.
Article in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Modelling ofFrontiers in physiology · 2022Article
- The Investigation of Metabonomic Pathways of Serum of Iranian Women with Recurrent Miscarriage UsingBioMed research international · 2021Article
- Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1).Cellular and molecular neurobiology · 2020Review
- TAAR Agonists.Cellular and molecular neurobiology · 2020Review
- Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages.Endocrine connections · 2018Article
- Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThyroid hormones play an important role in the maintenance of pregnancy. Their derivates, endogenous amines, act via binding to the trace amine-associated receptor (TAAR1). The aim of our study was to analyse the regulation of TAAR1, serine/threonine kinase (pGSK3β) and ornithine decarboxylase (ODC) in placentas of healthy pregnancies, spontaneous (SM) and recurrent miscarriages (RM) and to investigate the influence of thyroid hormone derivates on TAAR1 expression in trophoblast model cells
methodsPatients with SM (
resultsLevels of TAAR1, pGSK3β and ODC were higher in placentas of RM in comparison to healthy controls. Stimulation of BeWo cells with T
conclusionsUpregulation of placental TAAR1 may indicate an increased decarboxylation of thyroid hormones in miscarriages. Patients with RM may have a lack of T
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Registered trials
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