Evidence map›Paper›PMID 29472356›Full record

Trial reportHaematologica2018

A B-cell receptor-related gene signature predicts survival in mantle cell lymphoma: results from the Fondazione Italiana Linfomi MCL-0208 trial.

Riccardo Bomben, Simone Ferrero, Tiziana D'Agaro, Michele Dal Bo, Alessandro Re, Andrea Evangelista, Angelo Michele Carella, Alberto Zamò, Umberto Vitolo, Paola Omedè and 11 more

Open access · goldAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Journal of clinical medicine · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Molecular Pathogenesis of Mantle Cell Lymphoma.Hematology/oncology clinics of North America · 2020
    Review
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 2 countries.

Riccardo BombenClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy rbomben@cro.it.
Simone FerreroDepartment of Molecular Biotechnologies and Health Sciences, Hematology Division 1, University of Torino, Italy.
Tiziana D'AgaroClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy.
Michele Dal BoClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy.
Alessandro ReHematology, AO "Spedali Civili di Brescia", Italy.
Andrea EvangelistaUnit of Cancer Epidemiology, AOU "Città della Salute e della Scienza di Torino" University-Hospital, Italy.
Angelo Michele CarellaHematology Division 1, IRCCS AOU San Martino IST, Genova, Italy.
Alberto ZamòDepartment of Diagnostics and Public Health, University of Verona, Italy.
Umberto VitoloHematology Division 1, AOU "Città della Salute e della Scienza di Torino" University-Hospital, Italy.
Paola OmedèHematology Division 1, AOU "Città della Salute e della Scienza di Torino" University-Hospital, Italy.
Chiara RusconiHematology Division, "Niguarda Ca' Granda" Hospital, Milano, Italy.
Luca ArcainiHematology Division, Department of Molecular Medicine, IRCCS Fondazione San Matteo, Pavia, Italy.
Luigi RigacciHematology Division, AOU "Careggi", University of Firenze, Italy.
Stefano LuminariHematology, Azienda Sanitaria Locale IRCCS, Reggio Emilia, Italy.
Andrea PiccinDepartment of Hematology and BMT Unit, Bolzano/Bozen Regional Hospital, Italy.
Delong LiuHematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Adrian WiestnerHematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Gianluca GaidanoDivision of Haematology, Department of Translational Medicine -University of Eastern Piedmont, Novara, Italy.
Sergio CortelazzoHematology, Medical Oncology and Hematology Division, "Istituto Clinico Humanitas Gavazzeni", Bergamo, Italy.
Marco LadettoDepartment of Molecular Biotechnologies and Health Sciences, Hematology Division 1, University of Torino, Italy.
Valter GatteiClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITCentro di Riferimento Oncologico · ITNational Heart Lung and Blood Institute · USASL Roma · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITHumanitas Gavazzeni · ITOspedale di Bolzano · ITOspedale Policlinico San Martino · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Florence · ITUniversity of Turin · ITUniversity of Verona · IT

Funding

Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapyZIAHL002346 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WIESTNER, ADRIAN U · 2009 to 2025
$29.8M
Novel therapies for Mantle Cell Lymphoma: targets, mechanisms, and prognosisZIAHL005076 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WIESTNER, ADRIAN U · 2009 to 2019
$3.2M
6 · The paper itself

Abstract

Mantle cell lymphoma patients have variable clinical courses, ranging from indolent cases that do not require immediate treatment to aggressive, rapidly progressing diseases. Thus, diagnostic tools capable of stratifying patients according to their risk of relapse and death are needed. This study included 83 samples from the Fondazione Italiana Linfomi MCL-0208 clinical trial. Through gene expression profiling and quantitative real-time PCR we analyzed 46 peripheral blood and 43 formalin-fixed paraffin-embedded lymph node samples. A prediction model to classify patients was developed. By analyzing the transcriptome of 27 peripheral blood samples, two subgroups characterized by a differential expression of genes from the B-cell receptor pathway (B-cell receptor

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticAdultAgedBiomarkers, TumorFemaleFollow-Up StudiesHumansLymphoma, Mantle-CellMaleMiddle AgedPrognosisProspective StudiesReceptors, Antigen, B-CellSurvival RateBiomarkers, TumorReceptors, Antigen, B-Cell

Identifiers

PMID29472356
PMCPMC5927985
OpenAlexW2793357719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.