Evidence map›Paper›PMID 29472265›Full record

Trial reportBMJ open2018

Does early vitamin B

Brita Askeland Winje, Ingrid Kvestad, Srinivasan Krishnamachari, Karim Manji, Sunita Taneja, David C Bellinger, Nita Bhandari, Shruti Bisht, Anne Marie Darling, Christopher P Duggan and 8 more

4 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00197548 phase3completednot on this map

A Trial of Micronutrients and Adverse Pregnancy Outcomes

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2001 to 2006Enrolled8,468ConditionsPregnancy, Premature Birth, Infant, Low Birth Weight, Pregnancy OutcomesArmsMultivitamins-vitamins B-complex, C, and E, Placebo
NCT00421668 phase3completednot on this map

A Trial of Zinc and Micronutrients in Tanzanian Children

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2012Enrolled2,400ConditionsDiarrheal Illnesses, Respiratory Illness, Growth FalteringArmsZinc, Multivitamins, Placebo
NCT00641862 nacompletednot on this map

Randomized Trial of Vitamin B12 in Pregnant Indian Women

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2008 to 2011Enrolled366ConditionsPregnancyArmsVitamin B12, Placebo
NCT00717730 phase2completednot on this map

Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children

TypeinterventionalSponsorTor A. StrandRan2010 to 2011Enrolled1,000ConditionsDiarrhea, PneumoniaArmsFolic Acid, Vitamin B12, Placebo, Folic acid and vitamin B12
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  15. Article
  16. Efficacy of maternal BBMJ open · 2020
    Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 4 countries.

Brita Askeland WinjeDepartment of Vaccine Preventable Diseases, Norwegian Institute of Public Health, Oslo, Norway.
Ingrid KvestadRegional Centre for Child and Youth Mental Health and Child Welfare, Uni Research Health, Bergen, Norway.
Srinivasan KrishnamachariDivision of Mental Health and Neurosciences, St John's Research Institute, Bangalore, Karnataka, India.
Karim ManjiDepartment of Pediatrics and Child Health, Muhibili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Sunita TanejaCentre for Health Research and Development, Society for Applied Studies, New Delhi, Delhi, India.
David C BellingerDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Nita BhandariCentre for Health Research and Development, Society for Applied Studies, New Delhi, Delhi, India.
Shruti BishtDivision of Mental Health and Neurosciences, St John's Research Institute, Bangalore, Karnataka, India.
Anne Marie DarlingDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Christopher P DugganDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Wafaie FawziDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Mari HysingRegional Centre for Child and Youth Mental Health and Child Welfare, Uni Research Health, Bergen, Norway.
Tivendra KumarCentre for Health Research and Development, Society for Applied Studies, New Delhi, Delhi, India.
Anura V KurpadDivision of Mental Health and Neurosciences, St John's Research Institute, Bangalore, Karnataka, India.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Erling SvensenHaukeland University Hospital, Helse Bergen, Bergen, Norway.
Susan ThomasDivision of Mental Health and Neurosciences, St John's Research Institute, Bangalore, Karnataka, India.
Tor A StrandDepartment of Research, Innlandet Hospital Trust, Lillehammer, Norway.
Harvard Global Health Institute · USSociety for Applied Studies · INUni Research (Norway) · NOBoston Children's Hospital · USHaukeland University Hospital · NOInnlandet Hospital Trust · NOMuhimbili University of Health and Allied Sciences · TZNorwegian Institute of Public Health · NO

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
A Trial of Zinc and Micronutrients in Tanzanian ChildrenR01HD048969 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI DUGGAN, CHRISTOPHER P · 2006 to 2010
$2.0M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
MOLECULAR GENETICS OF EARLY-ONSET RECURRENT DEPRESSIONR01MH048969 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZUBENKO, GEORGE S · 1993 to 1997
–
NICHD NIH HHS R01 HD048969NICHD NIH HHS U54 HD090255NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561NIMH NIH HHS R01 MH048969
6 · The paper itself

Abstract

introductionAs many as 250 million children under the age of 5 may not be reaching their full developmental potential partly due to poor nutrition during pregnancy and the first 2 years of life. Micronutrients, including vitamin B METHODS AND ANALYSIS: In this project, we follow up children from four recently completed randomised placebo-controlled trials of oral vitamin B ETHICS AND DISSEMINATION: The study has received ethical approvals from all relevant authorities in Norway, USA, Tanzania and India and complies fully with ethical principles for medical research. Results will be presented at national and international research and policy meetings and published in peer-reviewed scientific journals, preferably open access. TRIAL REGISTRATION NUMBER: NCT00641862 (Bangalore); NCT00717730, updated CTRI/2016/11/007494 (Delhi); NCT00197548 and NCT00421668 (Dar es Salaam).

Indexed as

Dietary SupplementsChild DevelopmentChild, PreschoolCognitionFemaleFollow-Up StudiesHumansIndiaInfantLinear ModelsMaleMicronutrientsPregnancyResearch DesignTanzaniaVitamin B 12MicronutrientsVitamin B 12cognitive functionevent related potentialexecutive functiongrowthneurodevelopmentvitamin B12

Identifiers

PMID29472265
PMCPMC5855385
OpenAlexW2793830101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.