Evidence map›Paper›PMID 29472231›Full record

Observational studyArteriosclerosis, thrombosis, and vascular biology2018

Carotid Artery Remodeling Is Segment Specific: An In Vivo Study by Vessel Wall Magnetic Resonance Imaging.

Hiroko Watase, Jie Sun, Daniel S Hippe, Niranjan Balu, Feiyu Li, Xihai Zhao, Venkatesh Mani, Zahi A Fayad, Valentin Fuster, Thomas S Hatsukami and 1 more

Open access · bronzeAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Relationship Between Carotid Artery Remodeling Characteristics and Early Carotid Atherosclerosis: An Ultrasonographic Multicenter Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  3. Article
  4. Article
  5. Review
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  7. Article
  8. Review
  9. Article
  10. Hypertension and cognitive dysfunction: a narrative review.Journal of Yeungnam medical science · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Imaging Approaches to the Diagnosis of Vascular Diseases.Current atherosclerosis reports · 2022
    Review
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Hiroko WataseFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Jie SunFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Daniel S HippeFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Niranjan BaluFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Feiyu LiFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Xihai ZhaoFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Venkatesh ManiFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Zahi A FayadFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Valentin FusterFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Thomas S HatsukamiFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.).
Chun YuanFrom the Department of Surgery (H.W., T.S.H.) and Department of Radiology (J.S., D.S.H., N.B., C.Y.), University of Washington, Seattle; Department of Radiology, Peking University First Hospital, Beijing, China (F.L.); Department of Biomedical Engineering, Tsinghua University, Beijing, China (X.Z.); Translational and Molecular Imaging Institute (V.M., Z.A.F.) and Cardiovascular Institute (V.F.), Icahn School of Medicine at Mount Sinai, New York; and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (V.F.). cyuan@uw.edu.
Peking University First Hospital · CNTsinghua University · CNIcahn School of Medicine at Mount Sinai · USPeking University · CNSpanish National Centre for Cardiovascular Research · ES

Funding

MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
3D WALLI: MR intracranial vessel wall imaging for stroke preventionR01NS092207 · NINDS · UNIVERSITY OF WASHINGTON · PI MOSSA-BASHA, MAHMUD, YUAN, CHUN · 2016 to 2019
$3.1M
UW Medicine NINDS Stroke Trials Network Regional Coordinating Stroke CenterU10NS086525 · NINDS · UNIVERSITY OF WASHINGTON · PI TIRSCHWELL, DAVID L · 2013 to 2017
$1.9M
Culprit Plaque in Acute Cerebral Infarction: A Histological and MRI AssessmentR01NS083503 · NINDS · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS · 2013 to 2015
$598k
NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL103609NINDS NIH HHS R01 NS083503NINDS NIH HHS R01 NS092207NINDS NIH HHS U10 NS086525
6 · The paper itself

Abstract

objectiveEarly atherosclerosis is often undetected due in part to compensatory enlargement of the outer wall, termed positive remodeling. Variations in hemodynamic conditions and clinical factors influence the patterns of remodeling. The carotid artery provides an opportunity to examine these variations because of the unique geometry of the carotid bulb. This study aimed to determine differences in remodeling of the common, internal, and bifurcation segments of the carotid using magnetic resonance imaging. APPROACH AND

resultsCarotid arteries of 525 subjects without history of cardiovascular disease were imaged by magnetic resonance imaging. The carotid artery was divided into 3 segments: common carotid artery; bifurcation; and internal carotid artery. Remodeling patterns were characterized using linear regression analysis of lumen and total vessel areas (dependent variables) compared with maximum wall thickness (independent variable) for each segment, adjusted for age, sex, and height. The common carotid artery demonstrated a pattern consistent with positive remodeling, whereas the bifurcation demonstrated negative remodeling. The internal carotid artery demonstrated a mixed pattern of outer wall expansion and lumen constriction. Females and subjects with diabetes mellitus showed more positive remodeling, hypertension was associated with attenuated positive remodeling, and those with hypercholesterolemia showed more negative remodeling.

conclusionsIn this cohort of 55- to 80-year-old individuals without history of cardiovascular disease, the pattern of early carotid artery remodeling was segment specific and appeared to be associated with sex and clinical characteristics. These findings provide the groundwork for longitudinal studies to define local and systemic factors such as hemodynamic and clinical conditions on carotid artery remodeling.

Indexed as

Magnetic Resonance AngiographyVascular RemodelingAgedAged, 80 and overCarotid ArteriesCarotid Artery DiseasesChicagoCross-Sectional StudiesEarly DiagnosisFemaleFloridaHumansMaleMiddle AgedPredictive Value of TestsPrognosisatherosclerosiscarotid arterieshypercholesterolemiamagnetic resonance imagingregression analysis

Identifiers

PMID29472231
PMCPMC5965674
OpenAlexW2788193084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.