Evidence map›Paper›PMID 29471905›Full record

Trial reportThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018

Delay in seeking care for tuberculosis symptoms among adults newly diagnosed with HIV in rural Malawi.

L G Ngwira, D W Dowdy, M Khundi, G L Barnes, A Nkhoma, A T Choko, M Murowa, R E Chaisson, E L Corbett, K Fielding

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

L G NgwiraHIV & TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, Liverpool School of Tropical Medicine, Liverpool, UK.
D W DowdyCenter for TB Research, Johns Hopkins School of Medicine, Baltimore, Maryland, Department of Epidemiology, Department of International Health, Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland, USA.
M KhundiHIV & TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
G L BarnesCenter for TB Research, Johns Hopkins School of Medicine, Baltimore, Maryland.
A NkhomaHIV & TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
A T ChokoHIV & TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
M MurowaMinistry of Health, Lilongwe, Malawi.
R E ChaissonCenter for TB Research, Johns Hopkins School of Medicine, Baltimore, Maryland, Department of Epidemiology, Department of International Health, Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland, USA.
E L CorbettHIV & TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, TB Centre, London School of Hygiene & Tropical Medicine, London, UK.
K FieldingTB Centre, London School of Hygiene & Tropical Medicine, London, UK.
Malawi-Liverpool-Wellcome Trust Clinical Research Programme · MWJohns Hopkins University · USJohns Hopkins Medicine · USLiverpool School of Tropical Medicine · GBLondon School of Hygiene & Tropical Medicine · GBMinistry of Health · MWUniversity of Liverpool · GB

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Impact of a New Molecular TB Test on TB/HIV Outcomes among HIV-Infected MalawiansR01AI093316 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAISSON, RICHARD E. · 2011 to 2015
$2.8M
Medical Research Council MR/K012126/1NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI093316
6 · The paper itself

Abstract

settingTen primary health clinics in rural Thyolo District, Malawi.

objectiveTuberculosis (TB) is a common initial presentation of human immunodeficiency virus (HIV) infection. We investigated the time from TB symptom onset to HIV diagnosis to describe TB health-seeking behaviour in adults newly diagnosed with HIV.

designWe asked adults (18 years) about the presence and duration of TB symptoms at the time of receiving a new HIV diagnosis. Associations with delayed health seeking (defined as >30 and >90 days from the onset of TB symptoms) were evaluated using multivariable logistic regression.

resultsTB symptoms were reported by 416 of 1265 participants (33%), of whom 36% (150/416) had been symptomatic for >30 days before HIV testing. Most participants (260/416, 63%) were below the poverty line (US$0.41 per household member per day). Patients who first sought care from informal providers had an increased odds of delay of >30 days (adjusted odds ratio [aOR] 1.6, 95%CI 0.9-2.8) or 90 days (aOR 2.0, 95%CI 1.1-3.8).

conclusionsDelayed health seeking for TB-related symptoms was common. Poverty was ubiquitous, but had no clear relationship to diagnostic delay. HIV-positive individuals who first sought care from informal providers were more likely to experience diagnostic delays for TB symptoms.

Indexed as

AdultCoinfectionCross-Sectional StudiesDelayed DiagnosisFemaleHIV InfectionsHumansLogistic ModelsMalawiMaleMultivariate AnalysisPatient Acceptance of Health CarePovertyRural PopulationTime FactorsTuberculosis

Identifiers

PMID29471905
PMCPMC5824850
OpenAlexW2793877575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.