ArticleBMC cancer2018
Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Body mass index (BMI) and risk of lung cancer: a systematic review and meta-analysis of studies using directly measured and genetically proxied measures of BMI.Cancer causes & control : CCC · 2026Pooled it
- Racial difference in BMI and lung cancer diagnosis: analysis of the National Lung Screening Trial.BMC cancer · 2022Trial
- Metabolic profile and skeletal muscle as predictors of survival in testicular germ cell tumors.The oncologist · 2026Article
- Female-specific risk factors for lung cancer: insights from the All of Us Research Program.BMC public health · 2026Article
- Association between body-mass index change and lung cancer risk in Korea: nested case-control study.BMC cancer · 2025Observational
- Metabolome-Wide Mendelian Randomization Identifies Maleate as a Mediator of the Effect of Obesity on the Risk of Small Cell Lung Cancer.Food science & nutrition · 2025Article
- Leptin: A Heavyweight Player in Obesity-Related Cancers.Biomolecules · 2023Review
- Obesity and lung cancer-a narrative review.Journal of thoracic disease · 2023Review
- Diastole/Body Mass Index Ratio Can Predict Post-Thoracoscopic Surgery Metastasis in Stage I Lung Adenocarcinoma.Journal of personalized medicine · 2023Article
- Article
- Investigating the causal effects of smoking, sleep, and BMI on major depressive disorder and bipolar disorder: a univariable and multivariable two-sample Mendelian randomization study.Frontiers in psychiatry · 2023Article
- Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches.BMC cancer · 2022Observational
- Evaluating risk factors for lung cancer among never-smoking individuals using two Australian studies.Journal of cancer research and clinical oncology · 2022Article
- Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization.International journal of cancer · 2021Article
- Role of Omentin in Obesity Paradox in Lung Cancer.Cancers · 2021Article
- Article
- Statistical Assessment of Toxic and Essential Metals in the Serum of Female Patients with Lung Carcinoma from Pakistan.Biological trace element research · 2020Article
- Article
- The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape.Frontiers in oncology · 2020Article
- Predicted lean body mass, fat mass and risk of lung cancer: prospective US cohort study.European journal of epidemiology · 2019Article
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 7 countries.
Funding
Abstract
backgroundObesity has been proposed as a potential protective factor against lung cancer. We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four cohort studies.
methodsA case-control study was nested within four cohorts in USA, Europe, China and Singapore that included 4172 cases and 8471 control subjects. BMI at baseline was calculated as weight in kilograms divided by height in meters squared (kg/m
resultsConsidering all participants, and using normal weight as the reference group, a decreased risk of lung cancer was observed for those who were overweight (OR 0.77, 95% CI: 0.68-0.86) and obese (OR 0.69, 95% CI: 0.59-0.82). In the stratified analysis by smoking status, the decreased risk for lung cancer was observed among current, former and never smokers (P for interaction 0.002). The adjusted ORs for overweight and obese groups were 0.79 (95% CI: 0.68-0.92) and 0.75 (95% CI: 0.60-0.93) for current smokers, 0.70 (95% CI: 0.53-0.93) and 0.55 (95% CI: 0.37-0.80) for former smokers, 0.77 (95% CI: 0.59-0.99), and 0.71 (95% CI: 0.44-1.14) for never smokers, respectively. While no statistically significant association was observed for underweight subjects who were current smokers (OR 1.24, 95% CI: 0.98-1.58), former smokers (OR 0.27, 95% CI: 0.12-0.61) and never smokers (OR 0.83, 95% CI: 0.5.-1.28).
conclusionThe results of this study provide additional evidence that obesity is associated with a decreased risk of lung cancer. Further biological studies are needed to address this association.
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