ArticleBMC infectious diseases2018
Dengue score as a diagnostic predictor for pleural effusion and/or ascites: external validation and clinical application.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Derivation of a Simple Risk Scoring Scheme for Prediction of Severe Dengue Infection in Adult Patients in Thailand.Medical sciences (Basel, Switzerland) · 2025Article
- Using Data Mining to Differentiate Dengue with Warning Signs from Severe Dengue: A Predictive Model from Oaxaca, Mexico.The American journal of tropical medicine and hygiene · 2025Article
- Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital-Based Cross-Sectional Study.Health science reports · 2025Article
- Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) as a Novel Score in Early Detection of Complicated Dengue Fever.Journal of multidisciplinary healthcare · 2024Article
- Severity of Dengue Viral Infection Based on Clinical and Hematological Parameters among Pakistani Patients.The American journal of tropical medicine and hygiene · 2023Article
- Evaluation of remote radiologist-interpreted point-of-care ultrasound for suspected dengue patients in a primary health care facility in Colombia.Infectious diseases of poverty · 2023Article
- To study ultrasound and chest X-ray findings and their role in the diagnosis of dengue fever in children.Journal of family medicine and primary care · 2023Article
- Characterization of clinical patterns of dengue patients using an unsupervised machine learning approach.BMC infectious diseases · 2019Article
- Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study.BMC pediatrics · 2019Article
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3 authors.
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Abstract
backgroundThe Dengue Score is a model for predicting pleural effusion and/or ascites and uses the hematocrit (Hct), albumin concentration, platelet count and aspartate aminotransferase (AST) ratio as independent variables. As this metric has not been validated, we conducted a study to validate the Dengue Score and assess its clinical application.
methodsA retrospective study was performed at a private hospital in Jakarta, Indonesia. Patients with dengue infection hospitalized from January 2011 through March 2016 were included. The Dengue Score was calculated using four parameters: Hct increase≥15.1%, serum albumin≤3.49 mg/dL, platelet count≤49,500/μL and AST ratio ≥ 2.51. Each parameter was scored as 1 if present and 0 if absent. To validate the Dengue Score, goodness-of-fit was used to assess calibration, and the area under the receiver operating characteristic curve (AROC) was used to assess discrimination. Associations between clinical parameters and Dengue Score groups were determined by bivariate analysis.
resultsA total of 207 patients were included in this study. The calibration of the Dengue Score was acceptable (Hosmer-Lemeshow test, p = 0.11), and the score's discriminative ability was good (AROC = 0.88 (95% CI: 0.83-0.92)). At a cutoff of ≥2, the Dengue Score had a positive predictive value (PPV) of 79.03% and a negative predictive value (NPV) of 90.36% for the diagnostic prediction of pleural effusion and/or ascites. Compared with the Dengue Score ≤ 1 group, the Dengue Score = 2 group was significantly associated with hemoconcentration> 20% (p = 0.029), severe thrombocytopenia (p = 0.029), and increased length of hospital stay (p = 0.003). Compared with the Dengue Score = 2 group, the Dengue Score ≥ 3 group was significantly associated with hemoconcentration> 20% (p = 0.001), severe thrombocytopenia (p = 0.024), severe dengue (p = 0.039), and increased length of hospital stay (p = 0.011).
conclusionThe Dengue Score performed well and can be used in daily practice to help clinicians identify patients who have plasma leakage associated with severe dengue.
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