Evidence map›Paper›PMID 29471783›Full record

ArticleBMC infectious diseases2018

Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China.

Shuying Luo, Weihong Cui, Chan Li, Feng Ling, Tao Fu, Qiyong Liu, Jiangping Ren, Jimin Sun

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  11. Kinetics of IgG Antibodies in Previous Cases of Dengue Fever-A Longitudinal Serological Survey.International journal of environmental research and public health · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shuying LuoYiwu Municipal Center for Disease Control and Prevention, Yiwu, China.
Weihong CuiYantai Municipal Center for Disease Control and Prevention, Yantai, China.
Chan LiZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Feng LingZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Tao FuYiwu Municipal Center for Disease Control and Prevention, Yiwu, China.
Qiyong LiuState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Jiangping RenZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Jimin SunZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China. jmsun@cdc.zj.cn.
Zhejiang Center for Disease Control and Prevention · CNNational Institute for Communicable Disease Control and Prevention · CN

Funding

Medical Research Program of Zhejiang Province 2015RCA005National Basic Research Program of China 2012CB955504
6 · The paper itself

Abstract

backgroundCross-reacting antibodies enhanced dengue infection in humans and antibody dependent enhancement (ADE) have been proposed as early mechanisms underlying DHF/DSS. However, the duration of dengue IgG antibodies in the body as well as factors associated with said duration remain unclear.

methodsBlood samples from 59 dengue symptomatic persons and 48 asymptomatic individuals were collected. Study participant demographic information (including age in 2009, gender, and place of residence) were also collected. Serum samples were tested for dengue specific IgG by Panbio dengue IgG indirect enzyme-linked immunosorbent assay (ELISA). Chi-square tests and logistic regression analysis of dengue IgG antibodies seroprevalence divided by gender, age groups, and symptomatic or asymptomatic infection were conducted using the Statistical Package for the Social Sciences.

resultsOverall, 70 (65.42%) blood samples were seropositive for dengue IgG antibodies with similar seroprevalences found when dividing by gender and different age groups. However, seroprevalence of dengue IgG antibodies in samples from dengue symptomatic persons was significantly higher than that in samples from asymptomatic individuals (96.61% vs 27.08%) according to multivariable logistic regression analysis, the odds ratio (OR) of the factor was 76.731.

conclusionsDengue IgG antibodies were detectable in samples from most individuals three years after infection. Dengue symptomatic persons had a higher dengue IgG prevalence compared to asymptomatic individuals.

Indexed as

AdolescentAdultAgedAntibodies, ViralAsymptomatic InfectionsChildChild, PreschoolChinaDengueDengue VirusDisease OutbreaksEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GInfantAntibodies, ViralImmunoglobulin GAntibodyDengueDurationSeroprevalence

Identifiers

PMID29471783
PMCPMC5824482
OpenAlexW2806629654

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.