Evidence map›Paper›PMID 29471732›Full record

ArticleTissue engineering. Part B, Reviews2018

Large Animal Models of an In Vivo Bioreactor for Engineering Vascularized Bone.

Banu Akar, Alexander M Tatara, Alok Sutradhar, Hui-Yi Hsiao, Michael Miller, Ming-Huei Cheng, Antonios G Mikos, Eric M Brey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part B, Reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  11. Article
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  14. Biomaterials-aided mandibular reconstruction using in vivo bioreactors.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Review
  16. Journal of tissue engineering
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Banu Akar1 Biomedical Engineering, Illinois Institute of Technology , Chicago, Illinois.
Alexander M Tatara3 Department of Bioengineering, Rice University , Houston, Texas.
Alok Sutradhar5 Department of Mechanical and Aerospace Engineering, The Ohio State University , Columbus, Ohio.
Hui-Yi Hsiao6 Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital , Taoyuan, Taiwan .
Michael Miller8 Department of Plastic Surgery, The Ohio State University , Columbus, Ohio.
Ming-Huei Cheng6 Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital , Taoyuan, Taiwan .
Antonios G Mikos3 Department of Bioengineering, Rice University , Houston, Texas.
Eric M Brey1 Biomedical Engineering, Illinois Institute of Technology , Chicago, Illinois.

Funding

AN ENABLING TECHNOLOGY FOR PRECLINICAL X-RAY IMAGING OF BIOMATERIALS IN-VIVOR01EB020604 · NIBIB · WASHINGTON UNIVERSITY · PI ANASTASIO, MARK A, BREY, ERIC M · 2016 to 2019
$2.3M
NIBIB NIH HHS R01 EB020604
6 · The paper itself

Abstract

Reconstruction of large skeletal defects is challenging due to the requirement for large volumes of donor tissue and the often complex surgical procedures. Tissue engineering has the potential to serve as a new source of tissue for bone reconstruction, but current techniques are often limited in regards to the size and complexity of tissue that can be formed. Building tissue using an in vivo bioreactor approach may enable the production of appropriate amounts of specialized tissue, while reducing issues of donor site morbidity and infection. Large animals are required to screen and optimize new strategies for growing clinically appropriate volumes of tissues in vivo. In this article, we review both ovine and porcine models that serve as models of the technique proposed for clinical engineering of bone tissue in vivo. Recent findings are discussed with these systems, as well as description of next steps required for using these models, to develop clinically applicable tissue engineering applications.

Indexed as

BioreactorsBone and BonesModels, BiologicalSheepSwineAnimalsHumansTissue Engineeringbone regenerationlarge animal modelsovine modelperiosteumporcine model

Identifiers

PMID29471732
PMCPMC6080121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.