ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018
Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
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- Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.Signal transduction and targeted therapy · 2025Review
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- Protocol for rapid obtention and fractionation of anaerobic bacterial conditioned media to study calcium signaling in enteroendocrine cells.STAR protocols · 2022Article
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- The des-ArgFrontiers in physiology · 2022Article
- Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids.Membranes · 2021Review
- Liver regeneration observed across the different classes of vertebrates from an evolutionary perspective.Heliyon · 2021Review
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- Integrated analysis of gene modulation profile identifies pathogenic factors and pathways in the liver of diabetic mice.Journal of diabetes and metabolic disorders · 2019Article
- Expression of the type 3 InsPGut · 2019Article
- Emerging Role of HMGB1 in the Pathogenesis of Schistosomiasis Liver Fibrosis.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Hepatocyte proliferation during liver regeneration is a well-coordinated process regulated by the activation of several growth factor receptors, including the insulin receptor (IR). The IR can be localized in part to cholesterol-enriched membrane microdomains, but the role of such domains in insulin-mediated events in hepatocytes is not known. We investigated whether partitioning of IRs into cholesterol-enriched membrane rafts is important for the mitogenic effects of insulin in the hepatic cells. IR and lipid rafts were labeled in HepG2 cells and primary rat hepatocytes. Membrane cholesterol was depleted in vitro with metyl-β-cyclodextrin (MβCD) and in vivo with lovastatin. Insulin-induced calcium (Ca
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Registered trials
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