ArticleThe Journal of infectious diseases2018
Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Mapping the evolutionary path towards multi-drug resistance in the pandemicMicrobial genomics · 2026Article
- A posttranslational modification of fimbriae drives pathogenicity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Transmission dynamics of Escherichia coli sequence type 131 in households-a one health prospective cohort study.Nature communications · 2025Article
- Article
- Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.Veterinary research · 2025Article
- Characterization of novel sequence type 12531 and O8:H7 serotype carbapenem-resistantAntimicrobial agents and chemotherapy · 2024Article
- From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance.Annual review of microbiology · 2024Review
- Gut residentmedRxiv : the preprint server for health sciences · 2024Article
- Bladder-draining lymph nodes support germinal center B cell responses during urinary tract infection in mice.Infection and immunity · 2023Article
- Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract.PLoS biology · 2023Article
- Escherichia coli ST2797 Is Abundant in Wastewater and Might Be a Novel Emerging Extended-Spectrum Beta-Lactamase E. coli.Microbiology spectrum · 2023Article
- E. coli catheter-associated urinary tract infections are associated with distinctive virulence and biofilm gene determinants.JCI insight · 2023Article
- DegS protease regulates the motility, chemotaxis, and colonization ofFrontiers in microbiology · 2023Article
- Strain belonging to an emerging, virulent sublineage of ST131Frontiers in cellular and infection microbiology · 2023Article
- Role of aggregate-forming pilus (AFP) in adherence and colonization of both intestinal and urinary tracts.Virulence · 2022Article
- Article
- Infiltration of hidden antimicrobial resistance among healthy people in a Japanese community.JAC-antimicrobial resistance · 2022Article
- Does plasmid-based beta-lactam resistance increase E. coli infections: Modelling addition and replacement mechanisms.PLoS computational biology · 2022Article
- Innate Bacteriostatic Mechanisms Defend the Urinary Tract.Annual review of physiology · 2022Review
- Conserved FimH mutations in the globalComputational and structural biotechnology journal · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Background: Epidemiological studies point to the gut as a key reservoir of multidrug resistant Escherichia coli multilocus sequence type 131 (ST131), a globally dominant pathogenic clone causing urinary tract and bloodstream infections. Here we report a detailed investigation of its intestinal lifestyle. Methods: Clinical ST131 isolates and type 1 fimbriae null mutants were assessed for colonization of human intestinal epithelia and in mouse intestinal colonization models. Mouse gut tissue underwent histologic analysis for pathology and ST131 localization. Key findings were corroborated in mucus-producing human cell lines and intestinal biopsy specimens. Results: ST131 strains adhered to and invaded human intestinal epithelial cells more than probiotic and commensal strains. The reference ST131 strain EC958 established persistent intestinal colonization in mice, and expression of type 1 fimbriae mediated higher colonization levels. Bacterial loads were highest in the distal parts of the mouse intestine and did not cause any obvious pathology. Further analysis revealed that EC958 could bind to both mucus and underlying human intestinal epithelia. Conclusions: ST131 strains can efficiently colonize the mammalian gut and persist long term. Type 1 fimbriae enhance ST131 intestinal colonization, suggesting that mannosides, currently developed as therapeutics for bladder infections and Crohn's disease, could also be used to limit intestinal ST131 reservoirs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.