Evidence map›Paper›PMID 29471162›Full record

ArticleRedox biology2018

Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis.

Ashish K Singh, Rosanne Y Hertzberger, Ulla G Knaus

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review.Cellular and molecular gastroenterology and hepatology · 2021
    Pooled it
  2. Activity ofVirulence · 2026
    Article
  3. Article
  4. Review
  5. Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Evidence ofMicrobial genomics · 2024
    Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ashish K SinghConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Rosanne Y HertzbergerSwammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; NIZO Food Research, Ede, The Netherlands.
Ulla G KnausConway Institute, School of Medicine, University College Dublin, Dublin, Ireland. Electronic address: ulla.knaus@ucd.ie.
University College Dublin · IEUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease of the gastrointestinal tract, characterized by cycles of acute flares, recovery and remission phases. Treatments for accelerating tissue restitution and prolonging remission are scarce, but altering the microbiota composition to promote intestinal homeostasis is considered a safe, economic and promising approach. Although probiotic bacteria have not yet fulfilled fully their promise in clinical trials, understanding the mechanism of how they exert beneficial effects will permit devising improved therapeutic strategies. Here we probe if one of the defining features of lactobacilli, the ability to generate nanomolar H

Indexed as

AnimalsColitisDextran SulfateDisease Models, AnimalEpithelial CellsGene Expression RegulationHumansHydrogen PeroxideInflammatory Bowel DiseasesLactobacillusMiceMice, Inbred C57BLMicrobiotaDextran SulfateHydrogen PeroxideDSS colitisHydrogen peroxideInflammatory bowel diseaseLactobacilliMucosal healingTissue restitution

Identifiers

PMID29471162
PMCPMC5835490
OpenAlexW2793636430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.